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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMBOV561275:GHDN-2190-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:JTY_2167
OrganismiMycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Taxonomic identifieri561275 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Transmembranei55 – 7521HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10021HelicalUniRule annotationAdd
BLAST
Transmembranei117 – 13721HelicalUniRule annotationAdd
BLAST
Transmembranei156 – 17621HelicalUniRule annotationAdd
BLAST
Transmembranei187 – 20721HelicalUniRule annotationAdd
BLAST
Transmembranei231 – 25121HelicalUniRule annotationAdd
BLAST
Transmembranei255 – 27521HelicalUniRule annotationAdd
BLAST
Transmembranei280 – 30021HelicalUniRule annotationAdd
BLAST
Transmembranei334 – 35421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Phospho-N-acetylmuramoyl-pentapeptide-transferasePRO_1000117187Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC1AQ72.
SMRiC1AQ72. Positions 46-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275124.
KOiK01000.
OMAiHQNKKDT.
OrthoDBiEOG69GZPZ.

Family and domain databases

HAMAPiMF_00038. MraY.
InterProiIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERiPTHR22926. PTHR22926. 2 hits.
PfamiPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1AQ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQILIAVAV AVTVSILLTP VLIRLFTKQG FGHQIREDGP PSHHTKRGTP
60 70 80 90 100
SMGGVAILAG IWAGYLGAHL AGLAFDGEGI GASGLLVLGL ATALGGVGFI
110 120 130 140 150
DDLIKIRRSR NLGLNKTAKT VGQITSAVLF GVLVLQFRNA AGLTPGSADL
160 170 180 190 200
SYVREIATVT LAPVLFVLFC VVIVSAWSNA VNFTDGLDGL AAGTMAMVTA
210 220 230 240 250
AYVLITFWQY RNACVTAPGL GCYNVRDPLD LALIAAATAG ACIGFLWWNA
260 270 280 290 300
APAKIFMGDT GSLALGGVIA GLSVTSRTEI LAVVLGALFV AEITSVVLQI
310 320 330 340 350
LTFRTTGRRM FRMAPFHHHF ELVGWAETTV IIRFWLLTAI TCGLGVALFY

GEWLAAVGA
Length:359
Mass (Da):37,713
Last modified:May 26, 2009 - v1
Checksum:i27E979BC77BA28C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010918 Genomic DNA. Translation: BAH26451.1.
RefSeqiWP_003411171.1. NC_012207.1.

Genome annotation databases

EnsemblBacteriaiBAH26451; BAH26451; JTY_2167.
KEGGimbt:JTY_2167.
PATRICi18023994. VBIMycBov85238_2375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010918 Genomic DNA. Translation: BAH26451.1.
RefSeqiWP_003411171.1. NC_012207.1.

3D structure databases

ProteinModelPortaliC1AQ72.
SMRiC1AQ72. Positions 46-313.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH26451; BAH26451; JTY_2167.
KEGGimbt:JTY_2167.
PATRICi18023994. VBIMycBov85238_2375.

Phylogenomic databases

HOGENOMiHOG000275124.
KOiK01000.
OMAiHQNKKDT.
OrthoDBiEOG69GZPZ.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciMBOV561275:GHDN-2190-MONOMER.

Family and domain databases

HAMAPiMF_00038. MraY.
InterProiIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERiPTHR22926. PTHR22926. 2 hits.
PfamiPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains."
    Seki M., Honda I., Fujita I., Yano I., Yamamoto S., Koyama A.
    Vaccine 27:1710-1716(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCG / Tokyo 172 / ATCC 35737 / TMC 1019.

Entry informationi

Entry nameiMRAY_MYCBT
AccessioniPrimary (citable) accession number: C1AQ72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: November 11, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.