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C1AJZ7

- PCP_MYCBT

UniProt

C1AJZ7 - PCP_MYCBT

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Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, JTY_0329
Organism
Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801 By similarity
Active sitei146 – 1461 By similarity
Active sitei170 – 1701 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciMBOV561275:GHDN-333-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:JTY_0329
    OrganismiMycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
    Taxonomic identifieri561275 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000002205: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Pyrrolidone-carboxylate peptidaseUniRule annotation
    PRO_1000192223Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi561275.JTY_0329.

    Structurei

    3D structure databases

    ProteinModelPortaliC1AJZ7.
    SMRiC1AJZ7. Positions 4-205.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiERIAINC.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1AJZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVLVTGFG PYGVTPVNPA QLTAEELDGR TIAGATVISR IVPNTFFESI    50
    AAAQQAIAEI EPALVIMLGE YPGRSMITVE RLAQNVNDCG RYGLADCAGR 100
    VLVGEPTDPA GPVAYHATVP VRAMVLAMRK AGVPADVSDA AGTFVCNHLM 150
    YGVLHHLAQK GLPVRAGWIH LPCLPSVAAL DHNLGVPSMS VQTAVAGVTA 200
    GIEAAIRQSA DIREPIPSRL QI 222
    Length:222
    Mass (Da):23,193
    Last modified:May 26, 2009 - v1
    Checksum:iC542D9FD2CE2477D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010918 Genomic DNA. Translation: BAH24626.1.
    RefSeqiYP_002643394.1. NC_012207.1.

    Genome annotation databases

    EnsemblBacteriaiBAH24626; BAH24626; JTY_0329.
    GeneIDi7563059.
    KEGGimbt:JTY_0329.
    PATRICi18019915. VBIMycBov85238_0356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010918 Genomic DNA. Translation: BAH24626.1 .
    RefSeqi YP_002643394.1. NC_012207.1.

    3D structure databases

    ProteinModelPortali C1AJZ7.
    SMRi C1AJZ7. Positions 4-205.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 561275.JTY_0329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH24626 ; BAH24626 ; JTY_0329 .
    GeneIDi 7563059.
    KEGGi mbt:JTY_0329.
    PATRICi 18019915. VBIMycBov85238_0356.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi ERIAINC.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci MBOV561275:GHDN-333-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains."
      Seki M., Honda I., Fujita I., Yano I., Yamamoto S., Koyama A.
      Vaccine 27:1710-1716(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCG / Tokyo 172 / ATCC 35737 / TMC 1019.

    Entry informationi

    Entry nameiPCP_MYCBT
    AccessioniPrimary (citable) accession number: C1AJZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: September 3, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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