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C1AJN3

- TRMB_MYCBT

UniProt

C1AJN3 - TRMB_MYCBT

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821S-adenosyl-L-methionineUniRule annotation
    Binding sitei107 – 1071S-adenosyl-L-methionineUniRule annotation
    Binding sitei136 – 1361S-adenosyl-L-methionineUniRule annotation
    Active sitei159 – 1591By similarity
    Binding sitei159 – 1591S-adenosyl-L-methionineUniRule annotation
    Binding sitei163 – 1631SubstrateUniRule annotation
    Binding sitei195 – 1951SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMBOV561275:GHDN-217-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:JTY_0214
    OrganismiMycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
    Taxonomic identifieri561275 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000002205: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263tRNA (guanine-N(7)-)-methyltransferasePRO_1000149658Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561275.JTY_0214.

    Structurei

    3D structure databases

    ProteinModelPortaliC1AJN3.
    SMRiC1AJN3. Positions 47-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 2354Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiTSATNDY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1AJN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHHGQMHAQ PGVGLRPDTP VASGQLPSTS IRSRRSGISK AQRETWERLW    50
    PELGLLALPQ SPRGTPVDTR AWFGRDAPVV LEIGSGSGTS TLAMAKAEPH 100
    VDVIAVDVYR RGLAQLLCAI DKVGSDGINI RLILGNAVDV LQHLIAPDSL 150
    CGVRVFFPDP WPKARHHKRR LLQPATMALI ADRLVPSGVL HAATDHPGYA 200
    EHIAAAGDAE PRLVRVDPDT ELLPISVVRP ATKYERKAQL GGGAVIELLW 250
    KKHGCSERDL KIR 263
    Length:263
    Mass (Da):28,547
    Last modified:May 26, 2009 - v1
    Checksum:i5CECF14C9650AF07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010918 Genomic DNA. Translation: BAH24512.1.
    RefSeqiYP_002643280.1. NC_012207.1.

    Genome annotation databases

    EnsemblBacteriaiBAH24512; BAH24512; JTY_0214.
    GeneIDi7564216.
    KEGGimbt:JTY_0214.
    PATRICi18019677. VBIMycBov85238_0237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010918 Genomic DNA. Translation: BAH24512.1 .
    RefSeqi YP_002643280.1. NC_012207.1.

    3D structure databases

    ProteinModelPortali C1AJN3.
    SMRi C1AJN3. Positions 47-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561275.JTY_0214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH24512 ; BAH24512 ; JTY_0214 .
    GeneIDi 7564216.
    KEGGi mbt:JTY_0214.
    PATRICi 18019677. VBIMycBov85238_0237.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi TSATNDY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MBOV561275:GHDN-217-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains."
      Seki M., Honda I., Fujita I., Yano I., Yamamoto S., Koyama A.
      Vaccine 27:1710-1716(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCG / Tokyo 172 / ATCC 35737 / TMC 1019.

    Entry informationi

    Entry nameiTRMB_MYCBT
    AccessioniPrimary (citable) accession number: C1AJN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3