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C1AE25

- THIM_GEMAT

UniProt

C1AE25 - THIM_GEMAT

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate; via amide nitrogenUniRule annotation
Binding sitei131 – 1311ATPUniRule annotation
Binding sitei177 – 1771ATPUniRule annotation
Binding sitei204 – 2041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGAUR379066:GI3W-3763-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:GAU_3710
OrganismiGemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)
Taxonomic identifieri379066 [NCBI]
Taxonomic lineageiBacteriaGemmatimonadetesGemmatimonadalesGemmatimonadaceaeGemmatimonas
ProteomesiUP000002209: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Hydroxyethylthiazole kinasePRO_0000383863Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi379066.GAU_3710.

Structurei

3D structure databases

ProteinModelPortaliC1AE25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

C1AE25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAPSSASGP TQPRLSPADA LAALRASAPL TQCITNYVAM QIAANTLLAA
60 70 80 90 100
GAAPAMIHTV EESGAFAGLA RAVTINIGTL SPAWVDGMKA AIDGATAVGT
110 120 130 140 150
PWVLDPVAHY ASAYRSAVAR DLLSRRPTIL RGNASEILAL AGGNTAARGV
160 170 180 190 200
DAADPVTAAG AAASALAREY GSVVAVTGAV DLVTDGTRVA MVSGGSPWMP
210 220 230 240 250
QVTALGCSLT CLMGAFAAVT APLEATVAAL TLFAEAGARA HAHSEGPGSF
260 270
AWRFLDALAA VTPDDLTGTE RVSWNAP
Length:277
Mass (Da):27,690
Last modified:May 26, 2009 - v1
Checksum:i1F72F6FFAA444922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009153 Genomic DNA. Translation: BAH40752.1.
RefSeqiYP_002763222.1. NC_012489.1.

Genome annotation databases

EnsemblBacteriaiBAH40752; BAH40752; GAU_3710.
GeneIDi7706306.
KEGGigau:GAU_3710.
PATRICi21960438. VBIGemAur55831_3795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009153 Genomic DNA. Translation: BAH40752.1 .
RefSeqi YP_002763222.1. NC_012489.1.

3D structure databases

ProteinModelPortali C1AE25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 379066.GAU_3710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH40752 ; BAH40752 ; GAU_3710 .
GeneIDi 7706306.
KEGGi gau:GAU_3710.
PATRICi 21960438. VBIGemAur55831_3795.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci GAUR379066:GI3W-3763-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Gemmatimonas aurantiaca T-27 that represents a novel phylum Gemmatimonadetes."
    Takasaki K., Ichikawa N., Miura H., Matsushita S., Watanabe Y., Oguchi A., Ankai A., Yashiro I., Takahashi M., Terui Y., Fukui S., Yokoyama H., Tanikawa S., Hanada S., Kamagata Y., Fujita N.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T-27 / DSM 14586 / JCM 11422 / NBRC 100505.

Entry informationi

Entry nameiTHIM_GEMAT
AccessioniPrimary (citable) accession number: C1AE25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3