ID   C1A9I8_GEMAT            Unreviewed;       374 AA.
AC   C1A9I8;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=4-hydroxyphenylpyruvate dioxygenase {ECO:0000313|EMBL:BAH39165.1};
DE            EC=1.13.11.27 {ECO:0000313|EMBL:BAH39165.1};
GN   OrderedLocusNames=GAU_2123 {ECO:0000313|EMBL:BAH39165.1};
OS   Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC
OS   100505).
OC   Bacteria; Gemmatimonadota; Gemmatimonadetes; Gemmatimonadales;
OC   Gemmatimonadaceae; Gemmatimonas.
OX   NCBI_TaxID=379066 {ECO:0000313|EMBL:BAH39165.1, ECO:0000313|Proteomes:UP000002209};
RN   [1] {ECO:0000313|Proteomes:UP000002209}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T-27 / DSM 14586 / JCM 11422 / NBRC 100505
RC   {ECO:0000313|Proteomes:UP000002209};
RA   Takasaki K., Ichikawa N., Miura H., Matsushita S., Watanabe Y., Oguchi A.,
RA   Ankai A., Yashiro I., Takahashi M., Terui Y., Fukui S., Yokoyama H.,
RA   Tanikawa S., Hanada S., Kamagata Y., Fujita N.;
RT   "Complete genome sequence of Gemmatimonas aurantiaca T-27 that represents a
RT   novel phylum Gemmatimonadetes.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009283-1};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR009283-1};
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
CC       {ECO:0000256|ARBA:ARBA00005877}.
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DR   EMBL; AP009153; BAH39165.1; -; Genomic_DNA.
DR   RefSeq; WP_012683612.1; NC_012489.1.
DR   AlphaFoldDB; C1A9I8; -.
DR   STRING; 379066.GAU_2123; -.
DR   KEGG; gau:GAU_2123; -.
DR   eggNOG; COG3185; Bacteria.
DR   HOGENOM; CLU_034004_1_1_0; -.
DR   OrthoDB; 9780241at2; -.
DR   Proteomes; UP000002209; Chromosome.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   CDD; cd07250; HPPD_C_like; 1.
DR   CDD; cd08342; HPPD_N_like; 1.
DR   Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR   InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   NCBIfam; TIGR01263; 4HPPD; 1.
DR   PANTHER; PTHR11959; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; 1.
DR   PANTHER; PTHR11959:SF1; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   Pfam; PF14696; Glyoxalase_5; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000313|EMBL:BAH39165.1};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR009283-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR009283-1};
KW   Oxidoreductase {ECO:0000313|EMBL:BAH39165.1};
KW   Pyruvate {ECO:0000313|EMBL:BAH39165.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002209};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          20..150
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
FT   DOMAIN          177..331
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
FT   BINDING         180
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
FT   BINDING         263
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
FT   BINDING         342
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
SQ   SEQUENCE   374 AA;  41803 MW;  780FFCBE2D3E6C6D CRC64;
     MATLTTPEIG TEQDAFPING TDYVEFYVGN AKQASHYYRA AFGYSLVAYR GPETGVRDRA
     SYLMQQGKIR LVLTTSITAD TPIAEHVHRH GDGVRDYALW VDDARLAYET AIARGAIPIQ
     EPQVYSDEHG EVVIAAIGTY GDTIHSLVER RNYNGVFLPG FKAVTPHYQP SDVGLKYIDH
     CVGNVELGKM NQWVGYYADV LGFRNLITFD DTDINTEYSS LMSKVMANGN DRIKFPINEP
     ASGKKKSQIE EYLDFYGGPG AQHLALATDD ILATVTALRD RGVEFLSVPT SYYEDLQERV
     GKIDEKLEEL AALGILVDRD PDGYLLQIFT KPVEDRPTLF FEIIQRKGAT SFGKGNFRAL
     FEAIEREQEL RGNL
//