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C1A8L5 (UPPP_GEMAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:GAU_1533
OrganismGemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505) [Complete proteome] [HAMAP]
Taxonomic identifier379066 [NCBI]
Taxonomic lineageBacteriaGemmatimonadetesGemmatimonadalesGemmatimonadaceaeGemmatimonas

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000213151

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane244 – 26421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
C1A8L5 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: D9D2A38FDDBB1BF5

FASTA26729,033
        10         20         30         40         50         60 
MTVWQAIVLG IVQGLTEPLP VSSSAHLALT PYFLGWSDPG LAFDVALHFG TLLALIWYFR 

        70         80         90        100        110        120 
REWLEMIASA WRIARTRRVE TVHDRRVLYL IAATIPGGIG GLLLNDLAET TFRSPVVIAT 

       130        140        150        160        170        180 
SLIVMGILLW AVDRWSARAR VLEEVTLRDA IIVGCAQVLA LVPGVSRSGS TMTAGRLLKL 

       190        200        210        220        230        240 
DRPSVARFSF LMSMPITLAA VIVKMPDAVR EHGASLPLLA GVAAAAVSSW FAISVLLRYV 

       250        260 
ARHSFGVFAV YRVLLGIVVF ATLASRT 

« Hide

References

[1]"Complete genome sequence of Gemmatimonas aurantiaca T-27 that represents a novel phylum Gemmatimonadetes."
Takasaki K., Ichikawa N., Miura H., Matsushita S., Watanabe Y., Oguchi A., Ankai A., Yashiro I., Takahashi M., Terui Y., Fukui S., Yokoyama H., Tanikawa S., Hanada S., Kamagata Y., Fujita N.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T-27 / DSM 14586 / JCM 11422 / NBRC 100505.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009153 Genomic DNA. Translation: BAH38575.1.
RefSeqYP_002761045.1. NC_012489.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING379066.GAU_1533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH38575; BAH38575; GAU_1533.
GeneID7708422.
KEGGgau:GAU_1533.
PATRIC21955948. VBIGemAur55831_1579.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycGAUR379066:GI3W-1555-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_GEMAT
AccessionPrimary (citable) accession number: C1A8L5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families