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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciGAUR379066:G1G2N-1451-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:GAU_1425
OrganismiGemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)
Taxonomic identifieri379066 [NCBI]
Taxonomic lineageiBacteriaGemmatimonadetesGemmatimonadalesGemmatimonadaceaeGemmatimonas
Proteomesi
  • UP000002209 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei209 – 229HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21
Transmembranei272 – 294HelicalUniRule annotationAdd BLAST23
Transmembranei299 – 321HelicalUniRule annotationAdd BLAST23
Transmembranei357 – 377HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002020681 – 380Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST380

Interactioni

Protein-protein interaction databases

STRINGi379066.GAU_1425

Structurei

3D structure databases

SMRiC1A8A7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

C1A8A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYFLLQPLA RDVRLFNLLN YITFRAAAAF VTALLVSFIL GPAIIRRLRA
60 70 80 90 100
MAVHQVVREG TPDTHAGKGT TPTMGGLIIL AATFAPVLLW SRLSNRYVLL
110 120 130 140 150
AMAVTAWMGV IGFLDDYLKL KQKREGKKNE GLVERYKLAG QVLCGLGLGA
160 170 180 190 200
YLLLSPISTL PGASTTLPFF KYVLVVPAVA WAAWLYIPWV TFILTGVSNA
210 220 230 240 250
VNLTDGLDGL SSGLVAIAVL TLGLFAYVLG RVDTSAYLQV FYLRGAGELT
260 270 280 290 300
VFCAAVVGAC IGFLWYNAHP AQVFMGDTGS LALGGAVGAI AILLKSEFLL
310 320 330 340 350
LFVGAVFFAE TVSVILQRTV FKYRLRRYGR EYAQKHRVFR RAPLHHHFEM
360 370 380
MGWPETQVVV RFWIIGILCA ILALSTLKLR
Length:380
Mass (Da):41,751
Last modified:May 26, 2009 - v1
Checksum:i0515F5A94A1C0827
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009153 Genomic DNA Translation: BAH38467.1
RefSeqiWP_012682914.1, NC_012489.1

Genome annotation databases

EnsemblBacteriaiBAH38467; BAH38467; GAU_1425
KEGGigau:GAU_1425

Similar proteinsi

Entry informationi

Entry nameiMRAY_GEMAT
AccessioniPrimary (citable) accession number: C1A8A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: February 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health