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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:GAU_1425
OrganismiGemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)
Taxonomic identifieri379066 [NCBI]
Taxonomic lineageiBacteriaGemmatimonadetesGemmatimonadalesGemmatimonadaceaeGemmatimonas
Proteomesi
  • UP000002209 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei98 – 118HelicalUniRule annotationAdd BLAST21
Transmembranei142 – 162HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei209 – 229HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21
Transmembranei272 – 294HelicalUniRule annotationAdd BLAST23
Transmembranei299 – 321HelicalUniRule annotationAdd BLAST23
Transmembranei357 – 377HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002020681 – 380Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST380

Interactioni

Protein-protein interaction databases

STRINGi379066.GAU_1425.

Structurei

3D structure databases

SMRiC1A8A7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C1A8A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYFLLQPLA RDVRLFNLLN YITFRAAAAF VTALLVSFIL GPAIIRRLRA
60 70 80 90 100
MAVHQVVREG TPDTHAGKGT TPTMGGLIIL AATFAPVLLW SRLSNRYVLL
110 120 130 140 150
AMAVTAWMGV IGFLDDYLKL KQKREGKKNE GLVERYKLAG QVLCGLGLGA
160 170 180 190 200
YLLLSPISTL PGASTTLPFF KYVLVVPAVA WAAWLYIPWV TFILTGVSNA
210 220 230 240 250
VNLTDGLDGL SSGLVAIAVL TLGLFAYVLG RVDTSAYLQV FYLRGAGELT
260 270 280 290 300
VFCAAVVGAC IGFLWYNAHP AQVFMGDTGS LALGGAVGAI AILLKSEFLL
310 320 330 340 350
LFVGAVFFAE TVSVILQRTV FKYRLRRYGR EYAQKHRVFR RAPLHHHFEM
360 370 380
MGWPETQVVV RFWIIGILCA ILALSTLKLR
Length:380
Mass (Da):41,751
Last modified:May 26, 2009 - v1
Checksum:i0515F5A94A1C0827
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009153 Genomic DNA. Translation: BAH38467.1.
RefSeqiWP_012682914.1. NC_012489.1.

Genome annotation databases

EnsemblBacteriaiBAH38467; BAH38467; GAU_1425.
KEGGigau:GAU_1425.

Similar proteinsi

Entry informationi

Entry nameiMRAY_GEMAT
AccessioniPrimary (citable) accession number: C1A8A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: June 7, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families