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C1A482 (NADK_GEMAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:GAU_1865
OrganismGemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505) [Complete proteome] [HAMAP]
Taxonomic identifier379066 [NCBI]
Taxonomic lineageBacteriaGemmatimonadetesGemmatimonadalesGemmatimonadaceaeGemmatimonas

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289NAD kinase HAMAP-Rule MF_00361
PRO_1000205418

Regions

Nucleotide binding63 – 642NAD By similarity
Nucleotide binding138 – 1392NAD By similarity
Nucleotide binding179 – 1846NAD By similarity

Sites

Active site631Proton acceptor By similarity
Binding site681NAD By similarity
Binding site1491NAD By similarity
Binding site1681NAD By similarity
Binding site2381NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
C1A482 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 2566F9226AB5FC20

FASTA28930,966
        10         20         30         40         50         60 
MRVGVVGHRG YVGLPAVLNT LLDSAPALNF TLAFEEELWD MAEEGERLTQ DTPIDAMITL 

        70         80         90        100        110        120 
GGDGTLLRGA RLVNGRKIPI LGVNFGRLGF LTSCSADEME DGVQRLARGD FVSEPRMVLE 

       130        140        150        160        170        180 
SCAIDGDRSE RCRWRALNDV VMHKGGFARL VKFSVLVDGE HIGSYSADGL IISTPTGSTG 

       190        200        210        220        230        240 
YSLSAGGPIV MPTFESIVLT PVSPHTLAMR PLVLPADVEV TVRADDGPEE LLVTVDGQVG 

       250        260        270        280 
TTFTGGETLI VRRAPEPVHI VRLPGATFFT RLRHKLGWGG LSGRDGEAT 

« Hide

References

[1]"Complete genome sequence of Gemmatimonas aurantiaca T-27 that represents a novel phylum Gemmatimonadetes."
Takasaki K., Ichikawa N., Miura H., Matsushita S., Watanabe Y., Oguchi A., Ankai A., Yashiro I., Takahashi M., Terui Y., Fukui S., Yokoyama H., Tanikawa S., Hanada S., Kamagata Y., Fujita N.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T-27 / DSM 14586 / JCM 11422 / NBRC 100505.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009153 Genomic DNA. Translation: BAH38907.1.
RefSeqYP_002761377.1. NC_012489.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING379066.GAU_1865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH38907; BAH38907; GAU_1865.
GeneID7705769.
KEGGgau:GAU_1865.
PATRIC21956636. VBIGemAur55831_1913.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycGAUR379066:GI3W-1899-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_GEMAT
AccessionPrimary (citable) accession number: C1A482
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families