C1A2X7 (COAA_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	RER_42540

Organism

Rhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]

Taxonomic identifier

234621 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm By similarity HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Pantothenate kinase HAMAP MF_00215		PRO_1000204219
Regions
	Nucleotide binding	95 – 102	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	C1A2X7 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 7579C4DC21D85B20	FASTA	310	35,566
	10 20 30 40 50 60 MARTNESSPY VEFDRKQWRT LRKSTPLVLT EDELYGLRGL GEQIDLEEVA EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FAATATFLGE KHPDRQVPFV IGVAGSVAVG KSTTARVLQA LLARWDHHPR 130 140 150 160 170 180 VDLVTTDGFL YPTRELQRRG IMHRKGFPES YDRRKLLRFV TEVKSGAEEV AAPVYSHTSY 190 200 210 220 230 240 DIIPGQYHLI RQPDILIIEG LNVLQTGPRL MVSDLFDFSI YVDARIEDIE AWYIQRFLAL 250 260 270 280 290 300 RNTSFADPNA HFHHYSGLSD RDATIAAKEI WNSINHPNLV ENILPTRPRA TLVLRKDADH 310 TINRLRLRKL

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008957 Genomic DNA. Translation: BAH34962.1.
RefSeq	YP_002767701.1. NC_012490.1.
3D structure databases
ProteinModelPortal	C1A2X7.
ModBase	Search...
Protein-protein interaction databases
STRING	C1A2X7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7709745.
GenomeReviews	Gene locus RER_42540 in contig AP008957_GR.
KEGG	rer:RER_42540.
PATRIC	23195073. VBIRhoEry66701_4795.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_RHOE4

Accession

Primary (citable) accession number: C1A2X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program