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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Metal cation 1UniRule annotation
Metal bindingi22 – 221Metal cation 1UniRule annotation
Binding sitei22 – 221cAMPUniRule annotation
Metal bindingi61 – 611Metal cation 1UniRule annotation
Metal bindingi61 – 611Metal cation 2UniRule annotation
Binding sitei61 – 611cAMPUniRule annotation
Metal bindingi95 – 951Metal cation 2UniRule annotation
Metal bindingi167 – 1671Metal cation 2UniRule annotation
Metal bindingi205 – 2051Metal cation 2UniRule annotation
Metal bindingi207 – 2071Metal cation 1UniRule annotation
Binding sitei207 – 2071cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 962cAMPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRERY234621:GHDE-4123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:RER_40650
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
ProteomesiUP000002204 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3013013',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413376Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi234621.RER_40650.

Structurei

3D structure databases

ProteinModelPortaliC1A2D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238352.
OMAiIWAMGNH.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

C1A2D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRSAEYPR PKHFLVHLSD THLVAQGELY DAVDASTRLR EVLSGIVASG
60 70 80 90 100
ARPDALIFTG DLTDQGHPDA YAELKAIVEP VAAEIDAQVI WAMGNHDDRS
110 120 130 140 150
TFRSLLLGED ATDHPVDNVY DLDGLRVITL DSSVPGHHYG EISDRQLDWL
160 170 180 190 200
RSELAVPAPD GTILALHHPP VPCIQDLAVL VELRDQSRLA DVLRGSDVRA
210 220 230 240 250
ILAGHLHYST TATFAGIPVS VASSTCYTQD LNVEVGGQRG RDGAQGCNLV
260 270 280 290 300
HVYDETIVHS VVPLGAHVTV GEPVDADEGA RRLSAAGIRI LESEKAGRSI

V
Length:301
Mass (Da):32,343
Last modified:May 26, 2009 - v1
Checksum:iBA8DC406C6774B8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA. Translation: BAH34773.1.
RefSeqiWP_020908405.1. NC_012490.1.
YP_002767512.1. NC_012490.1.

Genome annotation databases

EnsemblBacteriaiBAH34773; BAH34773; RER_40650.
GeneIDi7711563.
KEGGirer:RER_40650.
PATRICi23194675. VBIRhoEry66701_4600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA. Translation: BAH34773.1.
RefSeqiWP_020908405.1. NC_012490.1.
YP_002767512.1. NC_012490.1.

3D structure databases

ProteinModelPortaliC1A2D8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi234621.RER_40650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH34773; BAH34773; RER_40650.
GeneIDi7711563.
KEGGirer:RER_40650.
PATRICi23194675. VBIRhoEry66701_4600.

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238352.
OMAiIWAMGNH.
OrthoDBiEOG6QG8GQ.

Enzyme and pathway databases

BioCyciRERY234621:GHDE-4123-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PR4 / NBRC 100887.

Entry informationi

Entry nameiCPDA_RHOE4
AccessioniPrimary (citable) accession number: C1A2D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 26, 2009
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.