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C1A2D8

- CPDA_RHOE4

UniProt

C1A2D8 - CPDA_RHOE4

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene
cpdA, RER_40650
Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Metal cation 1 By similarity
Metal bindingi22 – 221Metal cation 1 By similarity
Binding sitei22 – 221cAMP By similarity
Metal bindingi61 – 611Metal cation 1 By similarity
Metal bindingi61 – 611Metal cation 2 By similarity
Binding sitei61 – 611cAMP By similarity
Metal bindingi95 – 951Metal cation 2 By similarity
Metal bindingi167 – 1671Metal cation 2 By similarity
Metal bindingi205 – 2051Metal cation 2 By similarity
Metal bindingi207 – 2071Metal cation 1 By similarity
Binding sitei207 – 2071cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 962cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRERY234621:GHDE-4123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:RER_40650
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002204: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3013013',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotationPRO_0000413376Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi234621.RER_40650.

Structurei

3D structure databases

ProteinModelPortaliC1A2D8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238352.
OMAiFDGPHPF.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

C1A2D8-1 [UniParc]FASTAAdd to Basket

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MSVRSAEYPR PKHFLVHLSD THLVAQGELY DAVDASTRLR EVLSGIVASG    50
ARPDALIFTG DLTDQGHPDA YAELKAIVEP VAAEIDAQVI WAMGNHDDRS 100
TFRSLLLGED ATDHPVDNVY DLDGLRVITL DSSVPGHHYG EISDRQLDWL 150
RSELAVPAPD GTILALHHPP VPCIQDLAVL VELRDQSRLA DVLRGSDVRA 200
ILAGHLHYST TATFAGIPVS VASSTCYTQD LNVEVGGQRG RDGAQGCNLV 250
HVYDETIVHS VVPLGAHVTV GEPVDADEGA RRLSAAGIRI LESEKAGRSI 300
V 301
Length:301
Mass (Da):32,343
Last modified:May 26, 2009 - v1
Checksum:iBA8DC406C6774B8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH34773.1.
RefSeqiYP_002767512.1. NC_012490.1.

Genome annotation databases

EnsemblBacteriaiBAH34773; BAH34773; RER_40650.
GeneIDi7711563.
KEGGirer:RER_40650.
PATRICi23194675. VBIRhoEry66701_4600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH34773.1 .
RefSeqi YP_002767512.1. NC_012490.1.

3D structure databases

ProteinModelPortali C1A2D8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234621.RER_40650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH34773 ; BAH34773 ; RER_40650 .
GeneIDi 7711563.
KEGGi rer:RER_40650.
PATRICi 23194675. VBIRhoEry66701_4600.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000238352.
OMAi FDGPHPF.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci RERY234621:GHDE-4123-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PR4 / NBRC 100887.

Entry informationi

Entry nameiCPDA_RHOE4
AccessioniPrimary (citable) accession number: C1A2D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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