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C1A2D8

- CPDA_RHOE4

UniProt

C1A2D8 - CPDA_RHOE4

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201Metal cation 1UniRule annotation
    Metal bindingi22 – 221Metal cation 1UniRule annotation
    Binding sitei22 – 221cAMPUniRule annotation
    Metal bindingi61 – 611Metal cation 1UniRule annotation
    Metal bindingi61 – 611Metal cation 2UniRule annotation
    Binding sitei61 – 611cAMPUniRule annotation
    Metal bindingi95 – 951Metal cation 2UniRule annotation
    Metal bindingi167 – 1671Metal cation 2UniRule annotation
    Metal bindingi205 – 2051Metal cation 2UniRule annotation
    Metal bindingi207 – 2071Metal cation 1UniRule annotation
    Binding sitei207 – 2071cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi95 – 962cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRERY234621:GHDE-4123-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:RER_40650
    OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
    Taxonomic identifieri234621 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002204: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3013013',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413376Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi234621.RER_40650.

    Structurei

    3D structure databases

    ProteinModelPortaliC1A2D8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238352.
    OMAiFDGPHPF.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1A2D8-1 [UniParc]FASTAAdd to Basket

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    MSVRSAEYPR PKHFLVHLSD THLVAQGELY DAVDASTRLR EVLSGIVASG    50
    ARPDALIFTG DLTDQGHPDA YAELKAIVEP VAAEIDAQVI WAMGNHDDRS 100
    TFRSLLLGED ATDHPVDNVY DLDGLRVITL DSSVPGHHYG EISDRQLDWL 150
    RSELAVPAPD GTILALHHPP VPCIQDLAVL VELRDQSRLA DVLRGSDVRA 200
    ILAGHLHYST TATFAGIPVS VASSTCYTQD LNVEVGGQRG RDGAQGCNLV 250
    HVYDETIVHS VVPLGAHVTV GEPVDADEGA RRLSAAGIRI LESEKAGRSI 300
    V 301
    Length:301
    Mass (Da):32,343
    Last modified:May 26, 2009 - v1
    Checksum:iBA8DC406C6774B8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008957 Genomic DNA. Translation: BAH34773.1.
    RefSeqiYP_002767512.1. NC_012490.1.

    Genome annotation databases

    EnsemblBacteriaiBAH34773; BAH34773; RER_40650.
    GeneIDi7711563.
    KEGGirer:RER_40650.
    PATRICi23194675. VBIRhoEry66701_4600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008957 Genomic DNA. Translation: BAH34773.1 .
    RefSeqi YP_002767512.1. NC_012490.1.

    3D structure databases

    ProteinModelPortali C1A2D8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 234621.RER_40650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH34773 ; BAH34773 ; RER_40650 .
    GeneIDi 7711563.
    KEGGi rer:RER_40650.
    PATRICi 23194675. VBIRhoEry66701_4600.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238352.
    OMAi FDGPHPF.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci RERY234621:GHDE-4123-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PR4 / NBRC 100887.

    Entry informationi

    Entry nameiCPDA_RHOE4
    AccessioniPrimary (citable) accession number: C1A2D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3