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C1A1K2 (C1A1K2_RHOE4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412 EMBL BAH34487.1
Ordered Locus Names:RER_37790
OrganismRhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]
Taxonomic identifier234621 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Sequences

Sequence LengthMass (Da)Tools
C1A1K2 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: D8C4267A19BAE61D

FASTA42844,714
        10         20         30         40         50         60 
MTAVTSNAET VDSNASDTKS VVHDAARRAR KASRVLALLT TAQKDAALHA AADAVLAASD 

        70         80         90        100        110        120 
RILAANALDI DTAKAGGTEE SLLDRLRLTA DRIEGIASGL RQVAGLPDPI GEVLRGSTLP 

       130        140        150        160        170        180 
NGLELRQQRV PLGVVGMVYE ARPNVTVDAF GLTLKSGNAA LLRGSSSAVK SNEALVAALR 

       190        200        210        220        230        240 
ASLVAQGLPE DSVQLLPSAD RSTVTHLIQA RGLVDVVIPR GGAGLISAVV RDATVPTIET 

       250        260        270        280        290        300 
GVGNCHVYVH SAADLLMAEK ILLNSKTRRP SVCNTAETVL VDAAIAETAV PKLLQALQMH 

       310        320        330        340        350        360 
DVVVHGDLPG LVPATEDDWS KEYLTLDVAL KVVENLDAAV EHIDQYGTGH TEAIVTSDLS 

       370        380        390        400        410        420 
AAREFTARVD AAAVMVNAST AFTDGEQFGF GAEIGISTQK LHARGPMGLP ELTSTKWIVW 


GDGHTRPA

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008957 Genomic DNA. Translation: BAH34487.1.
RefSeqYP_002767226.1. NC_012490.1.

3D structure databases

ProteinModelPortalC1A1K2.
ModBaseSearch...

Protein-protein interaction databases

STRINGC1A1K2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7712736.
GenomeReviewsGene locus RER_37790 in contig AP008957_GR.
KEGGrer:RER_37790.
PATRIC23194057. VBIRhoEry66701_4303.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAQYPAACN.
ProtClustDBPRK00197.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC1A1K2_RHOE4
AccessionPrimary (citable) accession number: C1A1K2
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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