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C0ZZZ0

- MASZ_RHOE4

UniProt

C0ZZZ0 - MASZ_RHOE4

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Protein

Malate synthase G

Gene

glcB

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei276 – 2761Acetyl-CoAUniRule annotation
Binding sitei313 – 3131Acetyl-CoAUniRule annotation
Active sitei340 – 3401Proton acceptorUniRule annotation
Binding sitei340 – 3401GlyoxylateUniRule annotation
Metal bindingi435 – 4351MagnesiumUniRule annotation
Binding sitei435 – 4351GlyoxylateUniRule annotation
Metal bindingi463 – 4631MagnesiumUniRule annotation
Binding sitei544 – 5441Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei634 – 6341Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRERY234621:GHDE-3253-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:RER_32170
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002204: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Malate synthase GPRO_1000212377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei620 – 6201Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi234621.RER_32170.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni460 – 4634Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

C0ZZZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTERVQVGSL QVAKVLYDFV VEEALPGTGV DAETFWAGAD KVITELAPKN
60 70 80 90 100
RDLLAKRDDL QAQIDQWHRD HAGAPIDAAA YKAFLQEIGY LLPTPAEFSV
110 120 130 140 150
TTANVDTEIT STAGPQLVVP ILNARFALNA SNARWGSLYD ALYGTNAISE
160 170 180 190 200
ENGAEKGSGY NKVRGDKVIA WAREFLDAAA PLASGSHADS TKYVIDGSEL
210 220 230 240 250
KITLADGTVT TLAQPEKFVG YLGAKDAPTS ILLLNNGLHA EIQIDASSPI
260 270 280 290 300
GSTDAAGVKD VVLESAVTTI MDFEDSVAAV DADDKVVGYR NWLGLNRGDL
310 320 330 340 350
SEEIKKGAKS FTRTLNGDRK YTAVDGSELS LHGRSLLFVR NVGHLMTNPA
360 370 380 390 400
ILDADGNEVP EGILDALITS TCAVHGLSIS DANGPLDNSR TGSIYIVKPK
410 420 430 440 450
QHGPEEVAFT TELFGRVEQV LGLPENTLKV GIMDEERRTT VNLAACIKEA
460 470 480 490 500
VDRVVFINTG FLDRTGDEIH TSMEAGAMVR KAEMKKQKWI GAYEDWNVDT
510 520 530 540 550
GLACGLQGKA QIGKGMWAMT ELMADMLEQK IGHPKAGANT AWVPSPTGAT
560 570 580 590 600
LHATHYHRVD VFAVQDSLKG KPRASVDDIL TIPLAPSTDW TDAEKKEELD
610 620 630 640 650
NNCQSILGYV VRWIDAGVGC SKVPDIHDVA LMEDRATLRI SSQLLANWLR
660 670 680 690 700
HGIVSESDVV SALERMAPVV DRQNEGDAEY RNMAPDFDSN IAFQAAKELI
710 720
LEGAKQPSGY TEPILHRRRR EYKAANA
Length:727
Mass (Da):78,695
Last modified:May 26, 2009 - v1
Checksum:iBD7F5753677FE3C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA. Translation: BAH33925.1.
RefSeqiWP_020907832.1. NC_012490.1.
YP_002766664.1. NC_012490.1.

Genome annotation databases

EnsemblBacteriaiBAH33925; BAH33925; RER_32170.
GeneIDi7709397.
KEGGirer:RER_32170.
PATRICi23192880. VBIRhoEry66701_3723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA. Translation: BAH33925.1 .
RefSeqi WP_020907832.1. NC_012490.1.
YP_002766664.1. NC_012490.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234621.RER_32170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH33925 ; BAH33925 ; RER_32170 .
GeneIDi 7709397.
KEGGi rer:RER_32170.
PATRICi 23192880. VBIRhoEry66701_3723.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci RERY234621:GHDE-3253-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PR4 / NBRC 100887.

Entry informationi

Entry nameiMASZ_RHOE4
AccessioniPrimary (citable) accession number: C0ZZZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3