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C0ZZZ0

- MASZ_RHOE4

UniProt

C0ZZZ0 - MASZ_RHOE4

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Protein
Malate synthase G
Gene
glcB, RER_32170
Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei276 – 2761Acetyl-CoA By similarity
Binding sitei313 – 3131Acetyl-CoA By similarity
Active sitei340 – 3401Proton acceptor By similarity
Binding sitei340 – 3401Glyoxylate By similarity
Metal bindingi435 – 4351Magnesium By similarity
Binding sitei435 – 4351Glyoxylate By similarity
Metal bindingi463 – 4631Magnesium By similarity
Binding sitei544 – 5441Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei634 – 6341Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRERY234621:GHDE-3253-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:RER_32170
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002204: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Malate synthase GUniRule annotation
PRO_1000212377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei620 – 6201Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi234621.RER_32170.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarity
Regioni460 – 4634Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

C0ZZZ0-1 [UniParc]FASTAAdd to Basket

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MTERVQVGSL QVAKVLYDFV VEEALPGTGV DAETFWAGAD KVITELAPKN    50
RDLLAKRDDL QAQIDQWHRD HAGAPIDAAA YKAFLQEIGY LLPTPAEFSV 100
TTANVDTEIT STAGPQLVVP ILNARFALNA SNARWGSLYD ALYGTNAISE 150
ENGAEKGSGY NKVRGDKVIA WAREFLDAAA PLASGSHADS TKYVIDGSEL 200
KITLADGTVT TLAQPEKFVG YLGAKDAPTS ILLLNNGLHA EIQIDASSPI 250
GSTDAAGVKD VVLESAVTTI MDFEDSVAAV DADDKVVGYR NWLGLNRGDL 300
SEEIKKGAKS FTRTLNGDRK YTAVDGSELS LHGRSLLFVR NVGHLMTNPA 350
ILDADGNEVP EGILDALITS TCAVHGLSIS DANGPLDNSR TGSIYIVKPK 400
QHGPEEVAFT TELFGRVEQV LGLPENTLKV GIMDEERRTT VNLAACIKEA 450
VDRVVFINTG FLDRTGDEIH TSMEAGAMVR KAEMKKQKWI GAYEDWNVDT 500
GLACGLQGKA QIGKGMWAMT ELMADMLEQK IGHPKAGANT AWVPSPTGAT 550
LHATHYHRVD VFAVQDSLKG KPRASVDDIL TIPLAPSTDW TDAEKKEELD 600
NNCQSILGYV VRWIDAGVGC SKVPDIHDVA LMEDRATLRI SSQLLANWLR 650
HGIVSESDVV SALERMAPVV DRQNEGDAEY RNMAPDFDSN IAFQAAKELI 700
LEGAKQPSGY TEPILHRRRR EYKAANA 727
Length:727
Mass (Da):78,695
Last modified:May 26, 2009 - v1
Checksum:iBD7F5753677FE3C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH33925.1.
RefSeqiYP_002766664.1. NC_012490.1.

Genome annotation databases

EnsemblBacteriaiBAH33925; BAH33925; RER_32170.
GeneIDi7709397.
KEGGirer:RER_32170.
PATRICi23192880. VBIRhoEry66701_3723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH33925.1 .
RefSeqi YP_002766664.1. NC_012490.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234621.RER_32170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH33925 ; BAH33925 ; RER_32170 .
GeneIDi 7709397.
KEGGi rer:RER_32170.
PATRICi 23192880. VBIRhoEry66701_3723.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci RERY234621:GHDE-3253-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PR4 / NBRC 100887.

Entry informationi

Entry nameiMASZ_RHOE4
AccessioniPrimary (citable) accession number: C0ZZZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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