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C0ZZV7

- HIS1_RHOE4

UniProt

C0ZZV7 - HIS1_RHOE4

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Feedback inhibited by histidine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRERY234621:GHDE-3218-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
    Short name:
    ATP-PRTUniRule annotation
    Short name:
    ATP-PRTaseUniRule annotation
    Gene namesi
    Name:hisGUniRule annotation
    Ordered Locus Names:RER_31840
    OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
    Taxonomic identifieri234621 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002204: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283ATP phosphoribosyltransferasePRO_1000202536Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi234621.RER_31840.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0040.
    HOGENOMiHOG000223250.
    KOiK00765.
    OMAiYVMLDYD.
    OrthoDBiEOG66MQT3.

    Family and domain databases

    Gene3Di3.30.70.120. 1 hit.
    HAMAPiMF_00079. HisG_Long.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54913. SSF54913. 1 hit.
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0ZZV7-1 [UniParc]FASTAAdd to Basket

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    MLRVAVPNKG SLSESAAEIL SEAGYRRRTD SRDLTVLDPA NQVEFFFLRP    50
    KDIAIYVGSG ELDLGITGRD LAGDSGAPVS ERLSLGFGRS SFRYAAPAGK 100
    DWAVEDLSGL RIATSYPNLV RKDLTDRGLD ATVIRLDGAV EISIQLGVAD 150
    AIADVVGSGR TLRQHNLVAF GESLCDSEGV LIERTGAPQD DPARNQLIER 200
    VRGIVFAQQN LMIDYDCPRT ILDDAIKMTP GMESPTLSPL ADPDWVAVRA 250
    MVPIKGHNQV MDALAELGAK AILASNIRSV RAF 283
    Length:283
    Mass (Da):30,477
    Last modified:May 26, 2009 - v1
    Checksum:iE27600EB8BA96DB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008957 Genomic DNA. Translation: BAH33892.1.
    RefSeqiYP_002766631.1. NC_012490.1.

    Genome annotation databases

    EnsemblBacteriaiBAH33892; BAH33892; RER_31840.
    GeneIDi7709376.
    KEGGirer:RER_31840.
    PATRICi23192810. VBIRhoEry66701_3690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008957 Genomic DNA. Translation: BAH33892.1 .
    RefSeqi YP_002766631.1. NC_012490.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 234621.RER_31840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH33892 ; BAH33892 ; RER_31840 .
    GeneIDi 7709376.
    KEGGi rer:RER_31840.
    PATRICi 23192810. VBIRhoEry66701_3690.

    Phylogenomic databases

    eggNOGi COG0040.
    HOGENOMi HOG000223250.
    KOi K00765.
    OMAi YVMLDYD.
    OrthoDBi EOG66MQT3.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci RERY234621:GHDE-3218-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.120. 1 hit.
    HAMAPi MF_00079. HisG_Long.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54913. SSF54913. 1 hit.
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PR4 / NBRC 100887.

    Entry informationi

    Entry nameiHIS1_RHOE4
    AccessioniPrimary (citable) accession number: C0ZZV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3