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C0ZZD9

- FMT_RHOE4

UniProt

C0ZZD9 - FMT_RHOE4

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Protein

Methionyl-tRNA formyltransferase

Gene
fmt, RER_30160
Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciRERY234621:GHDE-3050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase (EC:2.1.2.9)
Gene namesi
Name:fmt
Ordered Locus Names:RER_30160
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002204: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Methionyl-tRNA formyltransferaseUniRule annotationPRO_1000203873Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi234621.RER_30160.

Structurei

3D structure databases

ProteinModelPortaliC0ZZD9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1134Tetrahydrofolate (THF) binding By similarity

Sequence similaritiesi

Belongs to the Fmt family.

Phylogenomic databases

eggNOGiCOG0223.
HOGENOMiHOG000261177.
KOiK00604.
OMAiRGDWFTP.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

C0ZZD9-1 [UniParc]FASTAAdd to Basket

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MRVVFAGTPE PAVPSLRRLI ESANHEVVAV VTRPDAVAGR GRKVTRSPIG    50
LLADEHGIPV LTPVKASDPD FAAELARLEP DCAPVVAYGN LLPQNVLDIP 100
KYGWVNLHFS LLPAWRGAAP VQAAISAGDE VTGASAFRLE AGMDTGPVYG 150
VMTERIRDTD TAGDLLGRLA ENGAALLESV LDGLEAGEIN AVPQSADGVS 200
YAPKVTVDAA RVRWELPART VDRHIRAVTP APGAWTMIGD LRVKVGPVTV 250
TDETLAVGEI SVRKDGLYIG TATTAVRLGQ IQPPGKKLMS AGDWARGARL 300
DAEVRAQ 307
Length:307
Mass (Da):32,363
Last modified:May 26, 2009 - v1
Checksum:i417188267440DDC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH33724.1.
RefSeqiYP_002766463.1. NC_012490.1.

Genome annotation databases

EnsemblBacteriaiBAH33724; BAH33724; RER_30160.
GeneIDi7709272.
KEGGirer:RER_30160.
PATRICi23192464. VBIRhoEry66701_3517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH33724.1 .
RefSeqi YP_002766463.1. NC_012490.1.

3D structure databases

ProteinModelPortali C0ZZD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234621.RER_30160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH33724 ; BAH33724 ; RER_30160 .
GeneIDi 7709272.
KEGGi rer:RER_30160.
PATRICi 23192464. VBIRhoEry66701_3517.

Phylogenomic databases

eggNOGi COG0223.
HOGENOMi HOG000261177.
KOi K00604.
OMAi RGDWFTP.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci RERY234621:GHDE-3050-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PR4 / NBRC 100887.

Entry informationi

Entry nameiFMT_RHOE4
AccessioniPrimary (citable) accession number: C0ZZD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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