C0ZZC3 (PYRB_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	RER_30000

Organism

Rhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]

Taxonomic identifier

234621 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000201599

Sequences

	Sequence		Length	Mass (Da)
	C0ZZC3 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 0E3B5BD3C8F8045F	FASTA	314	33,614
	10 20 30 40 50 60 MKHLLSIADL DRESAVELLD EAERFEQALL GREVRKLPTL RGRTVMTVFF ENSTRTRVSF 70 80 90 100 110 120 EVAGKWMSAD VINVSASSSS VSKGESLRDT AMTLRAAGAD ALIVRHPASG AAHQIAKWTG 130 140 150 160 170 180 AADDGGPAVI NAGDGTHEHP TQALLDALTL RQRLGDIEGK RIAIVGDILH SRVARSNALL 190 200 210 220 230 240 LSMLGAEVVL VAPPTLLPVG AHTWPVTVSH SLDAELPGLD AVLMLRVQAE RMNGGFFPSQ 250 260 270 280 290 300 REYSINYGLS EKRLAMLADH AVVLHPGPML RGMEIASAVA DSSKTAVLQQ VTNGVHMRMA 310 VLFRLLVGSE DGAL

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008957 Genomic DNA. Translation: BAH33708.1.
RefSeq	YP_002766447.1. NC_012490.1.
3D structure databases
ProteinModelPortal	C0ZZC3.
ModBase	Search...
Protein-protein interaction databases
STRING	C0ZZC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7712439.
GenomeReviews	Gene locus RER_30000 in contig AP008957_GR.
KEGG	rer:RER_30000.
PATRIC	23192432. VBIRhoEry66701_3501.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LQRERMS.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_RHOE4

Accession

Primary (citable) accession number: C0ZZC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program