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C0ZZB6 (AROB_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:RER_29930
OrganismRhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]
Taxonomic identifier234621 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3693693-dehydroquinate synthase HAMAP MF_00110
PRO_1000202919

Sequences

Sequence LengthMass (Da)Tools
C0ZZB6 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: EA72CB712AB95933

FASTA36938,960
        10         20         30         40         50         60 
MTEPVRVEVK TASPYPVVIG RGLLGDLVAE FDGARTVAIF HQPPLAETAE AVRAALAEKG 

        70         80         90        100        110        120 
IDAHRIEIPD AEDGKDLAVA GFCWDVLGRI GLTRSDAIMS LGGGAATDLT GFVAATWMRG 

       130        140        150        160        170        180 
VKVVHVPTTL LAMVDAAVGG KTGINTEAGK NLVGSFHEPG AVFIDLATLE TVPHNEIVAG 

       190        200        210        220        230        240 
MAEVIKTGFI ADPVILDLIE ADPKAALDPS GTVLPELIRR SVEVKAKVVA ADLRESDLRE 

       250        260        270        280        290        300 
ILNYGHTLGH AIERRERYKW RHGAAVSVGL VFAAELGRLA GRLDDATADR HKSILDLVGL 

       310        320        330        340        350        360 
PTSYDGDAFG DLMKGMQTDK KNRAGLLRFV VLDGLAKPGR LEGPDPSLLV AAYSAIARDP 


RPAGGTVLL

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008957 Genomic DNA. Translation: BAH33701.1.
RefSeqYP_002766440.1. NC_012490.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC0ZZB6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7715312.
GenomeReviewsGene locus RER_29930 in contig AP008957_GR.
KEGGrer:RER_29930.
PATRIC23192418. VBIRhoEry66701_3494.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAWMRGVRV.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_RHOE4
AccessionPrimary (citable) accession number: C0ZZB6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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