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C0ZYX0 (DCUP_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:RER_28470
OrganismRhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]
Taxonomic identifier234621 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000204238

Regions

Region36 – 405Substrate binding By similarity

Sites

Binding site851Substrate By similarity
Binding site1601Substrate By similarity
Binding site2151Substrate By similarity
Binding site3341Substrate By similarity
Site851Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
C0ZYX0 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 0CCD61600991953F

FASTA35537,355
        10         20         30         40         50         60 
MTGSAEYSAR RVLPDAPLLA AATGRTPSRR PVWFMRQAGR SLPEYREIRA GIGMLESCFD 

        70         80         90        100        110        120 
PALVCEITMQ PVRRHDVDAA ILFSDIVVPL KAAGIDLDIV AGVGPVVANP IRSIADVAAL 

       130        140        150        160        170        180 
PRLVPEEVGA IAQAVRLLTT ELGSTPLIGF AGAPFTLASY LVEGGPSRNH EKTKALMHSD 

       190        200        210        220        230        240 
PKTWHALLGS LADTTICFLQ TQLKAGVDAV QLFDSWAGAL SLADYREFVL PHSERVFAEV 

       250        260        270        280        290        300 
AAAGVPRIHF GVGTGELLGA MGEAGADVVG VDWRIPLDVA AGRVGPGKAL QGNLDPAVLF 

       310        320        330        340        350 
AGPEVIDREV RRIAAEGDRA IEAGAIGHIF NLGHGVLPDT DPTAITSAVE LVHSL

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008957 Genomic DNA. Translation: BAH33555.1.
RefSeqYP_002766294.1. NC_012490.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC0ZYX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7711386.
GenomeReviewsGene locus RER_28470 in contig AP008957_GR.
KEGGrer:RER_28470.
PATRIC23192104. VBIRhoEry66701_3343.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_RHOE4
AccessionPrimary (citable) accession number: C0ZYX0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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