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C0ZY25 (C0ZY25_RHOE4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183 EMBL BAH33260.1
Ordered Locus Names:RER_25520
OrganismRhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]
Taxonomic identifier234621 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding23 – 5230NADP By similarity HAMAP MF_00183

Sites

Metal binding1571Divalent metal cation By similarity HAMAP MF_00183
Metal binding1591Divalent metal cation By similarity HAMAP MF_00183
Metal binding2281Divalent metal cation By similarity HAMAP MF_00183
Binding site1341Substrate By similarity HAMAP MF_00183
Binding site1591Substrate By similarity HAMAP MF_00183
Binding site1831Substrate By similarity HAMAP MF_00183
Binding site2061Substrate By similarity HAMAP MF_00183
Binding site2281Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
C0ZY25 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 7EE1F3D584F9809F

FASTA39640,823
        10         20         30         40         50         60 
MFSGVIRNNG RVQETTRTRV LLLGSTGSIG TQALEVIAAN PDRFEVVGLA AGGNNVELLG 

        70         80         90        100        110        120 
EQIRATGVTN VAVADPAAAS ALQSVTARSG PSAVTELVRD SGADVVLNAL VGSLGLEPTL 

       130        140        150        160        170        180 
AALNSGARLA LANKESLVAG GALVTKAAAP GQIVPVDSEH SALAQCLRGG TGDEVARLVL 

       190        200        210        220        230        240 
TASGGPFRGW SAEDLESVNP AQAKAHPTWS MGPMNTLNSA TLVNKGLELI ETNLLFGIDY 

       250        260        270        280        290        300 
DRIDVTVHPQ SIVHSMVTFF DGSTLAQASP PDMKLPIALA LGWPDRIEGA ASACDFTTAS 

       310        320        330        340        350        360 
TWEFEPLDSS VFPAVDLARS AGKSGGCFTA IYNAANEVAA QAFLDGVISF PAIVRTVAAV 

       370        380        390 
LDDAGQWSAE PVTVDDVLAA DGWARTRARQ LVKQEG

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References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008957 Genomic DNA. Translation: BAH33260.1.
RefSeqYP_002765999.1. NC_012490.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC0ZY25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7714688.
GenomeReviewsGene locus RER_25520 in contig AP008957_GR.
KEGGrer:RER_25520.
PATRIC23191496. VBIRhoEry66701_3040.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0ZY25_RHOE4
AccessionPrimary (citable) accession number: C0ZY25
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info