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C0ZXN9 (DDL_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:RER_24160
OrganismRhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]
Taxonomic identifier234621 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000202203

Regions

Domain151 – 358208ATP-grasp
Nucleotide binding179 – 23456ATP By similarity

Sites

Metal binding3131Magnesium or manganese 1 By similarity
Metal binding3251Magnesium or manganese 1 By similarity
Metal binding3251Magnesium or manganese 2 By similarity
Metal binding3271Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
C0ZXN9 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: D0CB5348BCB9FEB5

FASTA36838,720
        10         20         30         40         50         60 
MNSSRTRVAV IFGGRSNEHS VSCVSAGSVL SNLDPDRYDV VPIGITVDGS WVLGSSDPSS 

        70         80         90        100        110        120 
LAISGRALPS VDKDGTSVVL SADPTREGEV ISFDGSDAGA VLASVDVVFP VLHGAYGEDG 

       130        140        150        160        170        180 
TIQGLLELAG VPYVGPGVLA SAAGMDKEFT KKLLAAEGLP VGVQVVLRPG IATLTEEQKA 

       190        200        210        220        230        240 
ELGLPVFVKP ARGGSSIGIT RVSNWDGLDG AIAHARLHDP KVIVEGAIIG REVECGVLEF 

       250        260        270        280        290        300 
PNGDVKASVV AEIRMPDADT DSDAFYDFDT KYLDDVCEFD IPAKLDESVS DQIRELAVRA 

       310        320        330        340        350        360 
FKALDCQGLS RVDFFVTADG PVINEINTMP GFTSISMYPK MWNATGIDYR TLISTLVDTA 


IARGTGLR 

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008957 Genomic DNA. Translation: BAH33124.1.
RefSeqYP_002765863.1. NC_012490.1.

3D structure databases

ProteinModelPortalC0ZXN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING234621.RER_24160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH33124; BAH33124; RER_24160.
GeneID7709925.
KEGGrer:RER_24160.
PATRIC23191260. VBIRhoEry66701_2922.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycRERY234621:GHDE-2443-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_RHOE4
AccessionPrimary (citable) accession number: C0ZXN9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways