C0ZWI9 (IOLG_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	RER_20160

Organism

Rhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]

Taxonomic identifier

234621 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_1000215886

Sequences

	Sequence		Length	Mass (Da)
	C0ZWI9 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 5E412B3190A3377A	FASTA	346	36,778
	10 20 30 40 50 60 MSDNQDLRIA VLGVGIMGAD HVDRITNKIG GARVTVVNDY SLARAEEIAA LTPGSRVVVD 70 80 90 100 110 120 PFDAIAAEDV DAVVLATPGP THEKQVLACL EAGKPVLCEK PLTTDADSSL AIVKAEAALG 130 140 150 160 170 180 KKLIQVGFMR RFDHEYTQLK YLIDSGDLGR PLVVHCAHRN PAVPNGFDSA MIVKDSLVHE 190 200 210 220 230 240 VDVTRFLLDE EITSVQIIRP SANSLAPEGI QDPQIAIFET ESGRHVDAEV FVTTGVAYEV 250 260 270 280 290 300 RTEVVGELGS AMIGLDVGLI RKTKPGNWGG QITPGFRERF GQAYDTEFAR WIKAVKTGAG 310 320 330 340 TGNYIDGPGA WDGYAAAAVC AAGVKSLETG QRVVVDMVAR DSVAGA

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008957 Genomic DNA. Translation: BAH32724.1.
RefSeq	YP_002765463.1. NC_012490.1.
3D structure databases
ProteinModelPortal	C0ZWI9.
ModBase	Search...
Protein-protein interaction databases
STRING	C0ZWI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7712086.
GenomeReviews	Gene locus RER_20160 in contig AP008957_GR.
KEGG	rer:RER_20160.
PATRIC	23190438. VBIRhoEry66701_2516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RTEVVGE.
ProtClustDB	CLSK956652.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RHOE4

Accession

Primary (citable) accession number: C0ZWI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program