C0ZUV7 (C0ZUV7_RHOE4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL BAH32352.1
Ordered Locus Names:	RER_16440

Organism

Rhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]

Taxonomic identifier

234621 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase RuleBase RU000515 EMBL BAH32352.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	198	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	250	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	235	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	208	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	219	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	276	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	315	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	C0ZUV7 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 7DFD97040092EBDE	FASTA	324	34,675
	10 20 30 40 50 60 MFPTHRPRRL RRTPALRRLV AETSLEPRHL VLPMFVADGI DTPREISSMP GVFQHTLDSL 70 80 90 100 110 120 RSAAVEAVEA GVGGLMLFGV PKAEDKDPQG SGASDPDGIL NVGLRALAEE LGDSTVIMAD 130 140 150 160 170 180 TCLDEFTDHG HCGVLNATGA VDNDATLIRY VEMALAQAES GAHLLGPSGM MDGQVAAIRG 190 200 210 220 230 240 ALDASGYVEV GQLAYAAKYA SAFYGPFREA VGSSLQGDRR TYQQDGANRR ESMREVDLDV 250 260 270 280 290 300 AEGADMVMVK PAMSYLDILR ETADRSPVPV AAYQISGEYS MITAAAQNGW IDRDAAILES 310 320 LTSIRRAGAD VVLTYWASEV AGWL

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008957 Genomic DNA. Translation: BAH32352.1.
RefSeq	YP_002765091.1. NC_012490.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C0ZUV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7713003.
GenomeReviews	Gene locus RER_16440 in contig AP008957_GR.
KEGG	rer:RER_16440.
PATRIC	23189660. VBIRhoEry66701_2131.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FTSHGHD.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C0ZUV7_RHOE4

Accession

Primary (citable) accession number: C0ZUV7

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)