Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

RER_15760

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.SAAS annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.SAAS annotation

Cofactori

Zn2+SAAS annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (RER_15760), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesisSAAS annotation
LigandMetal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00051; UER00082

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseSAAS annotation (EC:2.1.1.-SAAS annotation, EC:2.1.1.14SAAS annotation)
Gene namesi
Ordered Locus Names:RER_15760Imported
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)Imported
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002204 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi234621.RER_15760

Structurei

3D structure databases

ProteinModelPortaliC0ZUN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 326Meth_synt_1InterPro annotationAdd BLAST317
Domaini433 – 754Meth_synt_2InterPro annotationAdd BLAST322

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili577 – 597Sequence analysisAdd BLAST21
Coiled coili746 – 766Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4108KDZ Bacteria
COG0620 LUCA
HOGENOMiHOG000246221
KOiK00549
OMAiTCVQLDE
OrthoDBiPOG091H0282

Family and domain databases

Gene3Di3.20.20.2104 hits
InterProiView protein in InterPro
IPR013215 Cbl-indep_Met_Synth_N
IPR006276 Cobalamin-indep_Met_synthase
IPR002629 Met_Synth_C/arc
IPR038071 UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267 Meth_synt_1, 1 hit
PF01717 Meth_synt_2, 1 hit
PIRSFiPIRSF000382 MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726 SSF51726, 2 hits

Sequencei

Sequence statusi: Complete.

C0ZUN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSTAAFGS SVLGYPRIGP RRELKRALES YWHGTSDKDA LLAVAKELQE
60 70 80 90 100
STWSELAATG LSQVPGNTFS FYDHVLDNAL LFGAVPERFK PLEGALDPLD
110 120 130 140 150
FYFTMARGRP DFPPLELVRF FGTNYYYRQP EIDANTVFSL NSEALLDEFE
160 170 180 190 200
RAKARGIELR PVIMGPVSLL LLSKVGPATE KSDPNFTPLD LLDALLPEYE
210 220 230 240 250
KLFEQLAKAG ATCVQLDEPS VTEDRTPEEL AALGRAYEKL STAPLRPRLL
260 270 280 290 300
VTGPYGKFGE ALNILAPTKI EAFGLDLVHG KITAEELAAV PNIKRKRIYA
310 320 330 340 350
GVVDGRNVWR VDRFNTLTYL NELKDVVPDL VVSTSSSLLH VPYDVLSEYD
360 370 380 390 400
IPGDVADRLA FAKQKVGEVV SLAKALTEGP SDKWRKRPTK VHFKLKHAVR
410 420 430 440 450
ARVNAIKPED RVRAPYEERR KAQQERLNLP LVPAQTLGSF PQTDAIRQAR
460 470 480 490 500
YELGQGRLEW DDYYKRIQEE IERTIRLQED IGLDVFVHGE HERNDMVQYF
510 520 530 540 550
AELLEGYAFT HNGWVQAYGS RCTRPPILYG DIARPKPMTV EWIAYAQSLT
560 570 580 590 600
DKPVKGMLTG PVTMIARSFV RQDQPLYETA EQLALVIRDE IADLEAAGIA
610 620 630 640 650
IIQVDEPAIR ELLPLREDGR EAYLEWAVDA FRLATGGAKP ETQIHTHLTY
660 670 680 690 700
SARSSVVDAI ERLDADVTAI VATRSITWVL EALKEGALTH GVGPGVYESR
710 720 730 740 750
SARIPDIDEL DELLTEASES ISLDRLWANP DGGLKTRHPW QLEPSLRNMV
760
AAARRLRRRA EQAERDAG
Length:768
Mass (Da):86,009
Last modified:May 26, 2009 - v1
Checksum:iC532D284222D733B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA Translation: BAH32284.1
RefSeqiWP_019744430.1, NC_012490.1

Genome annotation databases

EnsemblBacteriaiBAH32284; BAH32284; RER_15760
GeneIDi31541342
KEGGirer:RER_15760
PATRICifig|234621.6.peg.2061

Similar proteinsi

Entry informationi

Entry nameiC0ZUN9_RHOE4
AccessioniPrimary (citable) accession number: C0ZUN9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported