C0ZU49 (ACDH2_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 2
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2

Gene names

Ordered Locus Names:

RER_57570

Organism

Rhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]

Taxonomic identifier

234621 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Acetaldehyde dehydrogenase 2 HAMAP MF_01657		PRO_0000387719
Regions
	Nucleotide binding	11 – 14	4	NAD By similarity
	Nucleotide binding	160 – 168	9	NAD By similarity
Sites
	Binding site	291	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	C0ZU49 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 76E50FE7F3C09B61	FASTA	314	33,095
	10 20 30 40 50 60 MSKVKVAIIG SGNIGTDLMI KVLRNSDYLE MGAMVGIDPA SDGLARAARL NVPITAEGVE 70 80 90 100 110 120 GLIGLPNFDE IEIVFDATSA KAHVANNARL APLGKRMIDL TPAAIGPYVV PAVNADEHLD 130 140 150 160 170 180 APNVNMVTCG GQATIPMVAA VSRVVPVAYA EIVASIASKS AGPGTRANID EFTETTSEAI 190 200 210 220 230 240 VAVGGARRGK AIIILNPAEP PLIMRDTVFC LVDAPDPAVH EEIRQSIEKM VGDVSAYVPG 250 260 270 280 290 300 YRLKQEVQIT EIPADQPVET LLVDGNRPTH QVSVFLEVEG AAHYLPAYAG NLDIMTSAGM 310 QIAERIAQQK EATK

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008957 Genomic DNA. Translation: BAH36465.1.
RefSeq	YP_002769204.1. NC_012490.1.
3D structure databases
ProteinModelPortal	C0ZU49.
ModBase	Search...
Protein-protein interaction databases
STRING	C0ZU49.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7715224.
GenomeReviews	Gene locus RER_57570 in contig AP008957_GR.
KEGG	rer:RER_57570.
PATRIC	23198180. VBIRhoEry66701_6339.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH2_RHOE4

Accession

Primary (citable) accession number: C0ZU49

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program