C0ZSI0 (C0ZSI0_RHOE4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

RER_54640

Organism

Rhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]

Taxonomic identifier

234621 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800 EMBL BAH36172.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C0ZSI0 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 9BD3A6E485CD7EC4	FASTA	421	45,893
	10 20 30 40 50 60 MTSTTTLSLD DCVKADAVDP LREFRREFAI PEGVLYFDGN SLGARPIAAQ ECAARVIGDE 70 80 90 100 110 120 WGNGLVRSWN EAGWFDLPVR LGDKLAPLLG AGEGEVVVTD STSINLFKAL ASALSIAAAQ 130 140 150 160 170 180 DPSRKVIVSE RDNFPTDLYI AEGIISLLDQ GYELRLIDQP GDLTEAVGPD TAVVMLSHVN 190 200 210 220 230 240 YRTGNLYAMT EVTAAVQERG ALMIWDLAHS AGAVTVDLSG ADADFAVGCT YKYLNGGPGS 250 260 270 280 290 300 PAFIWVNRRH QNTGIQPLSG WWGHARPFAM ESAYEPGAGI RRFLSGTQPI TSLSLVECGL 310 320 330 340 350 360 DVMLKADMAD IRSKSLALAD LFINLVEERC AAYGLELITP RAHERRGSHV SFVHPEGYSI 370 380 390 400 410 420 MKALIARGVI GDYREPGVLR FGITPLYLGY ADVWNAVDVL RDILENKSWD RPEFRERDAV T

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008957 Genomic DNA. Translation: BAH36172.1.
RefSeq	YP_002768911.1. NC_012490.1.
3D structure databases
ProteinModelPortal	C0ZSI0.
ModBase	Search...
Protein-protein interaction databases
STRING	C0ZSI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7710228.
GenomeReviews	Gene locus RER_54640 in contig AP008957_GR.
KEGG	rer:RER_54640.
PATRIC	23197560. VBIRhoEry66701_6029.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RGSQVSF.
ProtClustDB	CLSK866997.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. Kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C0ZSI0_RHOE4

Accession

Primary (citable) accession number: C0ZSI0

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)