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C0ZRU4 (C0ZRU4_RHOE4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL BAH31844.1
Ordered Locus Names:RER_11360
OrganismRhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]
Taxonomic identifier234621 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region260 – 2645ACP-binding By similarity HAMAP MF_01815

Sites

Active site1231 By similarity HAMAP MF_01815
Active site2591 By similarity HAMAP MF_01815
Active site2901 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
C0ZRU4 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: AAB6CFE20F89A5DF

FASTA34235,577
        10         20         30         40         50         60 
MGKPIASVAG GRQSVLLGLG VHRPERVVTN DEICELIDST DEWIQTRSGI KSRRFSGEGE 

        70         80         90        100        110        120 
GILAMSISAA RKALDVSGIA PEQIGAVIIA TSTWDLQTPQ AASIVAHELG IKGPAAFDVA 

       130        140        150        160        170        180 
AGCAGFCTAL AVASDLVRGG TVDHVLVVGV ELMSEATEPT DRSVRFIFGD GAGAVVVGPS 

       190        200        210        220        230        240 
DTVGIGPVEW GSDGSQSDAI VQEPSWLDYT KNPTGPRPWI KMAGTAVFRW AAFEMGKVAT 

       250        260        270        280        290        300 
RTLEKSGLGI EDIDAFVPHQ ANQRINEVIA RSMKLPEGFP VSNDIAETGN TSAASIPLAM 

       310        320        330        340 
EQMLRDGQCK PGDKALLLAF GAGLSFAGQV VVMPPLAGAE SA

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References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008957 Genomic DNA. Translation: BAH31844.1.
RefSeqYP_002764583.1. NC_012490.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC0ZRU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7710949.
GenomeReviewsGene locus RER_11360 in contig AP008957_GR.
KEGGrer:RER_11360.
PATRIC23188592. VBIRhoEry66701_1598.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMASNCFIFA.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK11608.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0ZRU4_RHOE4
AccessionPrimary (citable) accession number: C0ZRU4
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info