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C0ZRP8

- PCKG_RHOE4

UniProt

C0ZRP8 - PCKG_RHOE4

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, RER_10900
Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Substrate By similarity
Binding sitei226 – 2261Substrate; via amide nitrogen By similarity
Metal bindingi233 – 2331Manganese By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi253 – 2531Manganese; via tele nitrogen By similarity
Binding sitei275 – 2751Substrate By similarity
Active sitei277 – 2771 By similarity
Metal bindingi300 – 3001Manganese By similarity
Binding sitei392 – 3921GTP By similarity
Binding sitei423 – 4231GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2816GTP By similarity
Nucleotide bindingi518 – 5214GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRERY234621:GHDE-1108-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:RER_10900
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002204: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_1000206233Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi234621.RER_10900.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni390 – 3923Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0ZRP8-1 [UniParc]FASTAAdd to Basket

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MTSATIPGLN GTDGTPPTQH KELLAWVQEV AELTQPDRVV FADGSDEEWD    50
RLTTKLVEAG TFTRLNDEKK PNSFLGNSDP SDVARVESRT YICSKEEIDA 100
GPTNNWMDPA EMRTLMGDLY RGCMRGRTMY VVPFCMGPLD AEDPKLGVEL 150
TDSEYVVVSM RVMTRMGSKV LDKLGTDGFF VKALHSLGAP LADGQEDVAW 200
PCNDTKYITH FPEDREIWSF GSGYGGNALL GKKCYSLRIA SAMAHDEGWL 250
AEHMLILKLI SPEDKAYYIA AAFPSACGKT NLAMIQPTIP GWRAETLGDD 300
IAWMRFGEDG QLYAVNPEFG FFGVAPGTNW SSNPNAMRTI DQGNTVFTNV 350
ALTDDGDVWW EGLEGDPQHL IDWKGNEWTP ESGTHAAHPN SRYCTPMSQC 400
PIMAPEWDDP KGVPISAILF GGRRKTTVPL VTEARDWQHG VFMGATVGSE 450
QTAAAEGQVG TVRRDPMAML PFLGYNVGDY FQHWIDLGKS ADASKLPKVF 500
YVNWFRRGDD GRFLWPGFGE NSRVLKWIVE RIEHKAAGID TPIGVVPTGS 550
ALDIDGLDVS DADITEALAV NIDEWKAEIP LIEEWFDFVG EKLPTGIRDE 600
FEALKQRLA 609
Length:609
Mass (Da):67,398
Last modified:May 26, 2009 - v1
Checksum:i9B8F734434C0EB4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH31798.1.
RefSeqiYP_002764537.1. NC_012490.1.

Genome annotation databases

EnsemblBacteriaiBAH31798; BAH31798; RER_10900.
GeneIDi7710911.
KEGGirer:RER_10900.
PATRICi23188500. VBIRhoEry66701_1552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008957 Genomic DNA. Translation: BAH31798.1 .
RefSeqi YP_002764537.1. NC_012490.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234621.RER_10900.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH31798 ; BAH31798 ; RER_10900 .
GeneIDi 7710911.
KEGGi rer:RER_10900.
PATRICi 23188500. VBIRhoEry66701_1552.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci RERY234621:GHDE-1108-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PR4 / NBRC 100887.

Entry informationi

Entry nameiPCKG_RHOE4
AccessioniPrimary (citable) accession number: C0ZRP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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