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C0ZRJ1 (PUR7_RHOE4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:RER_10330
OrganismRhodococcus erythropolis (strain PR4 / NBRC 100887) [Complete proteome] [HAMAP]
Taxonomic identifier234621 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000203238

Sequences

Sequence LengthMass (Da)Tools
C0ZRJ1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 70718AFFB9034D6E

FASTA29732,412
        10         20         30         40         50         60 
MRPTLDSYTH LAGGKVRDLY TIDDEHLLLV ASDRISAYDH VLSTPIPDKG RVLTAMSVFF 

        70         80         90        100        110        120 
FNVLGGTNHL AGEPDDDRIP EEVLGRALVV RSLDMVPVEC VVRGFLTGSG LVDYNNTGAV 

       130        140        150        160        170        180 
CGVALPEGLV EASRLPDPIF TPASKAALGD HDENISFDQV VEKVGQKLAV QLREDTLDVY 

       190        200        210        220        230        240 
ARASNFAADR GIILADTKLE FGLDSGGNLV LADEVLTPDS SRYWPLEGYE AGKVQPSFDK 

       250        260        270        280        290 
QFVRDWLTSP ESGWDRSSDT TPPPLPQEIV DATRARYIEA YERISGLSFD DWVGPSA

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PR4 / NBRC 100887.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008957 Genomic DNA. Translation: BAH31741.1.
RefSeqYP_002764480.1. NC_012490.1.

3D structure databases

ProteinModelPortalC0ZRJ1.
ModBaseSearch...

Protein-protein interaction databases

STRINGC0ZRJ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7714803.
GenomeReviewsGene locus RER_10330 in contig AP008957_GR.
KEGGrer:RER_10330.
PATRIC23188380. VBIRhoEry66701_1492.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALTLMDEV.
ProtClustDBPRK13961.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR00081. PurC. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_RHOE4
AccessionPrimary (citable) accession number: C0ZRJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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