Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpm

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpm), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpm)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei62SubstrateUniRule annotation1
Active sitei89Proton donor/acceptorUniRule annotation1
Sitei183Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmImported
Synonyms:gpmAUniRule annotation
Ordered Locus Names:RER_08400Imported
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)Imported
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002204 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi234621.RER_08400.

Structurei

3D structure databases

ProteinModelPortaliC0ZQ70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 17Substrate bindingUniRule annotation8
Regioni89 – 92Substrate bindingUniRule annotation4
Regioni116 – 117Substrate bindingUniRule annotation2
Regioni184 – 185Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiNLHAVGP.
OrthoDBiPOG091H02BM.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiView protein in InterPro
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiView protein in Pfam
PF00300. His_Phos_1. 2 hits.
SMARTiView protein in SMART
SM00855. PGAM. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiView protein in PROSITE
PS00175. PG_MUTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

C0ZQ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTHLILLR HGESTWNADD RFAGWVDIPL TDGGREEAIR AGHAITEAAV
60 70 80 90 100
LPDVVHTSLL RRAISTANTV LDTTDRHWIP VRRTWRLNER HYGALQGCSR
110 120 130 140 150
GDIRDKFGAD QFKRWRRSFD EAPPPLEPGS PWGQDREIRY QSSCVDVPKT
160 170 180 190 200
ESLHDVTTRL LPHWTGSVVP DLRSGKTVLV VAHGNVLRTL LIHLHGIPRS
210 220
EADQIQISTG EPLWLTLDES LRPM
Length:224
Mass (Da):25,258
Last modified:May 26, 2009 - v1
Checksum:i391DED17E58E4822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA. Translation: BAH31548.1.
RefSeqiWP_020906236.1. NC_012490.1.

Genome annotation databases

EnsemblBacteriaiBAH31548; BAH31548; RER_08400.
KEGGirer:RER_08400.
PATRICifig|234621.6.peg.1294.

Similar proteinsi

Entry informationi

Entry nameiC0ZQ70_RHOE4
AccessioniPrimary (citable) accession number: C0ZQ70
Entry historyiIntegrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported