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C0ZPX0

- ACDH1_RHOE4

UniProt

C0ZPX0 - ACDH1_RHOE4

Protein

Acetaldehyde dehydrogenase 1

Gene

RER_07400

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261Acyl-thioester intermediateUniRule annotation
    Binding sitei276 – 2761NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi157 – 1659NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRERY234621:GHDE-757-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
    Gene namesi
    Ordered Locus Names:RER_07400
    OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
    Taxonomic identifieri234621 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002204: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Acetaldehyde dehydrogenase 1PRO_0000387718Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi234621.RER_07400.

    Structurei

    3D structure databases

    ProteinModelPortaliC0ZPX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiDIQQYVP.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0ZPX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKASVAIVG SGNISTDLLY KLQRSEWLEP RWMIGIDPES EGLARARKMG    50
    LETSAEGVDW LLSQAEKPDL VFEATSAYVH REAAPRYEAA GIRAIDLTPA 100
    AVGPAVVPPA NLREHLDAPN VNMITCGGQA TIPIVYAVSR VVDVAYAEIV 150
    ASVASLSAGP GTRANIDEFT KTTSRGIETI GGAQRGKAII ILNPADPPMI 200
    MRDTIFCAIP EDADQAAITD SIHRVVKDIQ QYVPGYRLLN EPQFDKPSVV 250
    SGGYATVTTF VEVEGAGDFL PPYAGNLDIM TAAATKVGEE IAQKLLSVKA 300
    Length:300
    Mass (Da):31,948
    Last modified:May 26, 2009 - v1
    Checksum:iDB6574359F5DE4C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008957 Genomic DNA. Translation: BAH31448.1.
    RefSeqiYP_002764187.1. NC_012490.1.

    Genome annotation databases

    EnsemblBacteriaiBAH31448; BAH31448; RER_07400.
    GeneIDi7711924.
    KEGGirer:RER_07400.
    PATRICi23187772. VBIRhoEry66701_1189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008957 Genomic DNA. Translation: BAH31448.1 .
    RefSeqi YP_002764187.1. NC_012490.1.

    3D structure databases

    ProteinModelPortali C0ZPX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 234621.RER_07400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH31448 ; BAH31448 ; RER_07400 .
    GeneIDi 7711924.
    KEGGi rer:RER_07400.
    PATRICi 23187772. VBIRhoEry66701_1189.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi DIQQYVP.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci RERY234621:GHDE-757-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PR4 / NBRC 100887.

    Entry informationi

    Entry nameiACDH1_RHOE4
    AccessioniPrimary (citable) accession number: C0ZPX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3