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C0ZKC8

- PUR5_BREBN

UniProt

C0ZKC8 - PUR5_BREBN

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBRE358681:GHYS-695-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:BBR47_06020
    OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
    Taxonomic identifieri358681 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
    ProteomesiUP000001877: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148270Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi358681.BBR47_06020.

    Structurei

    3D structure databases

    ProteinModelPortaliC0ZKC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiNPQENDI.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0ZKC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEAYKQAGV DIDAGNEAVE RMKKHVKRTF RPEVMTDLGG FGALFRLDTK    50
    KYEKPILVSG TDGVGTKLKL AFAMDKHDTI GIDAVAMCVN DVVVQGAEPL 100
    FFLDYLAVDK VIPEKIEAIV KGIAEGCSQS GCSLIGGETA EMPGMYAEGE 150
    YDIAGFTVGV VDESKMITGA SVAAGDVLIG LASSGVHSNG FSLVRKVLLA 200
    DKGMSLHDHV DVLGKKLGEE LLTPTRIYVK QVLSVLESHE VKALVHITGG 250
    GFTENIPRVL PEGMQAVINV GSWPVLPIFE LVQGAGNISY PDMYKTFNMG 300
    IGMMLVVKPE DAVSVMEKLQ ELGEQAYLIG NIQAGERKVV YNGVEW 346
    Length:346
    Mass (Da):37,155
    Last modified:May 26, 2009 - v1
    Checksum:i5A487D255F8B81A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH41579.1.
    RefSeqiYP_002770083.1. NC_012491.1.

    Genome annotation databases

    EnsemblBacteriaiBAH41579; BAH41579; BBR47_06020.
    GeneIDi7716333.
    KEGGibbe:BBR47_06020.
    PATRICi21231488. VBIBreBre96763_0598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH41579.1 .
    RefSeqi YP_002770083.1. NC_012491.1.

    3D structure databases

    ProteinModelPortali C0ZKC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 358681.BBR47_06020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH41579 ; BAH41579 ; BBR47_06020 .
    GeneIDi 7716333.
    KEGGi bbe:BBR47_06020.
    PATRICi 21231488. VBIBreBre96763_0598.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi NPQENDI.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci BBRE358681:GHYS-695-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Brevibacillus brevis strain 47, complete genome."
      Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
      , Udaka S., Tanikawa S., Fujita N.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 47 / JCM 6285 / NBRC 100599.

    Entry informationi

    Entry nameiPUR5_BREBN
    AccessioniPrimary (citable) accession number: C0ZKC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3