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C0ZKC8

- PUR5_BREBN

UniProt

C0ZKC8 - PUR5_BREBN

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, BBR47_06020
Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBRE358681:GHYS-695-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:BBR47_06020
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
ProteomesiUP000001877: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000148270Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_06020.

Structurei

3D structure databases

ProteinModelPortaliC0ZKC8.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C0ZKC8-1 [UniParc]FASTAAdd to Basket

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MSEAYKQAGV DIDAGNEAVE RMKKHVKRTF RPEVMTDLGG FGALFRLDTK    50
KYEKPILVSG TDGVGTKLKL AFAMDKHDTI GIDAVAMCVN DVVVQGAEPL 100
FFLDYLAVDK VIPEKIEAIV KGIAEGCSQS GCSLIGGETA EMPGMYAEGE 150
YDIAGFTVGV VDESKMITGA SVAAGDVLIG LASSGVHSNG FSLVRKVLLA 200
DKGMSLHDHV DVLGKKLGEE LLTPTRIYVK QVLSVLESHE VKALVHITGG 250
GFTENIPRVL PEGMQAVINV GSWPVLPIFE LVQGAGNISY PDMYKTFNMG 300
IGMMLVVKPE DAVSVMEKLQ ELGEQAYLIG NIQAGERKVV YNGVEW 346
Length:346
Mass (Da):37,155
Last modified:May 26, 2009 - v1
Checksum:i5A487D255F8B81A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH41579.1.
RefSeqiYP_002770083.1. NC_012491.1.

Genome annotation databases

EnsemblBacteriaiBAH41579; BAH41579; BBR47_06020.
GeneIDi7716333.
KEGGibbe:BBR47_06020.
PATRICi21231488. VBIBreBre96763_0598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH41579.1 .
RefSeqi YP_002770083.1. NC_012491.1.

3D structure databases

ProteinModelPortali C0ZKC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 358681.BBR47_06020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH41579 ; BAH41579 ; BBR47_06020 .
GeneIDi 7716333.
KEGGi bbe:BBR47_06020.
PATRICi 21231488. VBIBreBre96763_0598.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci BBRE358681:GHYS-695-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Brevibacillus brevis strain 47, complete genome."
    Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
    , Udaka S., Tanikawa S., Fujita N.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 47 / JCM 6285 / NBRC 100599.

Entry informationi

Entry nameiPUR5_BREBN
AccessioniPrimary (citable) accession number: C0ZKC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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