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C0ZIF7

- SYC_BREBN

UniProt

C0ZIF7 - SYC_BREBN

Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi29 – 291ZincUniRule annotation
    Metal bindingi209 – 2091ZincUniRule annotation
    Metal bindingi234 – 2341ZincUniRule annotation
    Metal bindingi238 – 2381ZincUniRule annotation
    Binding sitei269 – 2691ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBBRE358681:GHYS-248-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
    Alternative name(s):
    Cysteinyl-tRNA synthetaseUniRule annotation
    Short name:
    CysRSUniRule annotation
    Gene namesi
    Name:cysSUniRule annotation
    Ordered Locus Names:BBR47_01980
    OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
    Taxonomic identifieri358681 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
    ProteomesiUP000001877: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Cysteine--tRNA ligasePRO_1000199045Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi358681.BBR47_01980.

    Structurei

    3D structure databases

    ProteinModelPortaliC0ZIF7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi31 – 4111"HIGH" regionAdd
    BLAST
    Motifi266 – 2705"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0215.
    HOGENOMiHOG000245250.
    KOiK01883.
    OMAiEPDEIAW.
    OrthoDBiEOG6RVFXC.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00041. Cys_tRNA_synth.
    InterProiIPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR10890. PTHR10890. 1 hit.
    PfamiPF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view]
    PRINTSiPR00983. TRNASYNTHCYS.
    SMARTiSM00840. DALR_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00435. cysS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0ZIF7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIQLTNTMT RRKEPFHTLE PGKVKMYVCG PTVYNYIHIG NARPAIVFDT    50
    LRRYLKYRGY EVTFVQNITD VDDKLIRVAN QEGVTVKEVA DRYTDAYNAD 100
    LKSLNVSPPD IQPRVMQTIP EIIEFVQGLI EKGFAYESEG DVYFRTGRFQ 150
    EYGKLSHQPL DDLQAGARVE INEKKEHPLD FVLWKAAKTG EVTWDSPWGE 200
    GRPGWHIECS AMALKFLGEE IDIHAGGTDL VFPHHENEIA QSECFTGKVF 250
    ARYWLHNGML NIDNEKMSKS LGNFLLARDL SEKFGGQLIR FFMLQGHYRN 300
    PINFSEELIE QAANGLDRIT TAYTNLSHRL DTARAEEPND QAQEQARIIG 350
    ELRERFIAEM DDDINTANAI TVIFDVVKEA NLYLRHQNVG ETEVRAYMDL 400
    LVELTEVLGL DIAEEQELLD SEIDALIEER TEARKARNFA RSDEIRDLLA 450
    AKGIVLEDTP QGVRWRRK 468
    Length:468
    Mass (Da):53,604
    Last modified:May 26, 2009 - v1
    Checksum:i813F1022FA502311
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH41175.1.
    RefSeqiYP_002769679.1. NC_012491.1.

    Genome annotation databases

    EnsemblBacteriaiBAH41175; BAH41175; BBR47_01980.
    GeneIDi7720579.
    KEGGibbe:BBR47_01980.
    PATRICi21230608. VBIBreBre96763_0201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH41175.1 .
    RefSeqi YP_002769679.1. NC_012491.1.

    3D structure databases

    ProteinModelPortali C0ZIF7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 358681.BBR47_01980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH41175 ; BAH41175 ; BBR47_01980 .
    GeneIDi 7720579.
    KEGGi bbe:BBR47_01980.
    PATRICi 21230608. VBIBreBre96763_0201.

    Phylogenomic databases

    eggNOGi COG0215.
    HOGENOMi HOG000245250.
    KOi K01883.
    OMAi EPDEIAW.
    OrthoDBi EOG6RVFXC.

    Enzyme and pathway databases

    BioCyci BBRE358681:GHYS-248-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00041. Cys_tRNA_synth.
    InterProi IPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR10890. PTHR10890. 1 hit.
    Pfami PF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view ]
    PRINTSi PR00983. TRNASYNTHCYS.
    SMARTi SM00840. DALR_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00435. cysS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Brevibacillus brevis strain 47, complete genome."
      Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
      , Udaka S., Tanikawa S., Fujita N.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 47 / JCM 6285 / NBRC 100599.

    Entry informationi

    Entry nameiSYC_BREBN
    AccessioniPrimary (citable) accession number: C0ZIF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3