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Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29ZincUniRule annotation1
Metal bindingi209ZincUniRule annotation1
Metal bindingi234ZincUniRule annotation1
Metal bindingi238ZincUniRule annotation1
Binding sitei269ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBBRE358681:G1G2J-249-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
Alternative name(s):
Cysteinyl-tRNA synthetaseUniRule annotation
Short name:
CysRSUniRule annotation
Gene namesi
Name:cysSUniRule annotation
Ordered Locus Names:BBR47_01980
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
Proteomesi
  • UP000001877 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001990451 – 468Cysteine--tRNA ligaseAdd BLAST468

Proteomic databases

PRIDEiC0ZIF7

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi358681.BBR47_01980

Structurei

3D structure databases

ProteinModelPortaliC0ZIF7
SMRiC0ZIF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 41"HIGH" regionAdd BLAST11
Motifi266 – 270"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8N Bacteria
COG0215 LUCA
HOGENOMiHOG000245250
KOiK01883
OMAiHECEIAQ
OrthoDBiPOG091H004K

Family and domain databases

CDDicd00672 CysRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00041 Cys_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR015803 Cys-tRNA-ligase
IPR015273 Cys-tRNA-synt_Ia_DALR
IPR024909 Cys-tRNA/MSH_ligase
IPR014729 Rossmann-like_a/b/a_fold
IPR032678 tRNA-synt_1_cat_dom
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR10890 PTHR10890, 1 hit
PfamiView protein in Pfam
PF09190 DALR_2, 1 hit
PF01406 tRNA-synt_1e, 1 hit
PRINTSiPR00983 TRNASYNTHCYS
SMARTiView protein in SMART
SM00840 DALR_2, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
TIGRFAMsiTIGR00435 cysS, 1 hit

Sequencei

Sequence statusi: Complete.

C0ZIF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIQLTNTMT RRKEPFHTLE PGKVKMYVCG PTVYNYIHIG NARPAIVFDT
60 70 80 90 100
LRRYLKYRGY EVTFVQNITD VDDKLIRVAN QEGVTVKEVA DRYTDAYNAD
110 120 130 140 150
LKSLNVSPPD IQPRVMQTIP EIIEFVQGLI EKGFAYESEG DVYFRTGRFQ
160 170 180 190 200
EYGKLSHQPL DDLQAGARVE INEKKEHPLD FVLWKAAKTG EVTWDSPWGE
210 220 230 240 250
GRPGWHIECS AMALKFLGEE IDIHAGGTDL VFPHHENEIA QSECFTGKVF
260 270 280 290 300
ARYWLHNGML NIDNEKMSKS LGNFLLARDL SEKFGGQLIR FFMLQGHYRN
310 320 330 340 350
PINFSEELIE QAANGLDRIT TAYTNLSHRL DTARAEEPND QAQEQARIIG
360 370 380 390 400
ELRERFIAEM DDDINTANAI TVIFDVVKEA NLYLRHQNVG ETEVRAYMDL
410 420 430 440 450
LVELTEVLGL DIAEEQELLD SEIDALIEER TEARKARNFA RSDEIRDLLA
460
AKGIVLEDTP QGVRWRRK
Length:468
Mass (Da):53,604
Last modified:May 26, 2009 - v1
Checksum:i813F1022FA502311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA Translation: BAH41175.1
RefSeqiWP_012683966.1, NC_012491.1

Genome annotation databases

EnsemblBacteriaiBAH41175; BAH41175; BBR47_01980
GeneIDi29257511
KEGGibbe:BBR47_01980

Similar proteinsi

Entry informationi

Entry nameiSYC_BREBN
AccessioniPrimary (citable) accession number: C0ZIF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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