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Protein

Imidazolonepropionase

Gene

hutI

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.UniRule annotation

Cofactori

Zn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 1 zinc or iron ion per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 3 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Zinc or ironUniRule annotation1
Metal bindingi87Zinc or ironUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei107SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei190SubstrateUniRule annotation1
Metal bindingi255Zinc or ironUniRule annotation1
Binding sitei258SubstrateUniRule annotation1
Metal bindingi329Zinc or ironUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBBRE358681:G1G2J-4327-MONOMER
UniPathwayiUPA00379; UER00551

Protein family/group databases

MEROPSiM38.980

Names & Taxonomyi

Protein namesi
Recommended name:
ImidazolonepropionaseUniRule annotation (EC:3.5.2.7UniRule annotation)
Alternative name(s):
Imidazolone-5-propionate hydrolaseUniRule annotation
Gene namesi
Name:hutIUniRule annotation
Ordered Locus Names:BBR47_42290
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001338811 – 424ImidazolonepropionaseAdd BLAST424

Proteomic databases

PRIDEiC0ZHT2

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_42290

Structurei

3D structure databases

ProteinModelPortaliC0ZHT2
SMRiC0ZHT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. HutI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI2 Bacteria
COG1228 LUCA
HOGENOMiHOG000218460
KOiK01468
OMAiCMMRAGT
OrthoDBiPOG091H0EIK

Family and domain databases

CDDicd01296 Imidazolone-5PH, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_00372 HutI, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR005920 HutI
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR42752 PTHR42752, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01224 hutI, 1 hit

Sequencei

Sequence statusi: Complete.

C0ZHT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPVWIRHA SQLATLAGGS SSPVVGAKMN ELSIIEDGSI WLEDGVIQRV
60 70 80 90 100
GTDEDLALHY RDRTHEAQII DASGKLVTPG LIDPHTHLVH AGSRQNEFNM
110 120 130 140 150
RLNGATYMEI MNNGGGIHST TAATRAATHE ELFAQSKQRL DQFLLHGVTT
160 170 180 190 200
VEAKSGYGLT LEDELKQLEV AKQLNEAHPI DIVSTFMGAH AVPREYKENP
210 220 230 240 250
DAFVDMVIEE MIPEVARRKL AVFNDVFCER GVFTPEQSRR ILEAGVRHGL
260 270 280 290 300
LPKIHADEIE PYEGAELAAS VGAVSADHLL RASDKGIEQM AEAGVIAVLL
310 320 330 340 350
PGTAFFLMAE SANGRKMIDR GVAVAISTDC NPGSSPTVSL PLIMNLGCLK
360 370 380 390 400
MGMTPAEVLT AATINAAHAI RCAHEVGSLE VGKKADVTIF DVPDFMTLQY
410 420
RYGINHVNTV IKNGTIVVAE GRLA
Length:424
Mass (Da):45,811
Last modified:May 26, 2009 - v1
Checksum:iFAFBBECDF817321A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA Translation: BAH45206.1
RefSeqiWP_015892472.1, NC_012491.1

Genome annotation databases

EnsemblBacteriaiBAH45206; BAH45206; BBR47_42290
GeneIDi29261479
KEGGibbe:BBR47_42290

Entry informationi

Entry nameiHUTI_BREBN
AccessioniPrimary (citable) accession number: C0ZHT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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