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Protein

Imidazolonepropionase

Gene

hutI

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.UniRule annotation

Cofactori

Zn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 1 zinc or iron ion per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 3 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Zinc or ironUniRule annotation1
Metal bindingi87Zinc or ironUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei107SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei190SubstrateUniRule annotation1
Metal bindingi255Zinc or ironUniRule annotation1
Binding sitei258SubstrateUniRule annotation1
Metal bindingi329Zinc or ironUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Histidine metabolism

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00379; UER00551.

Protein family/group databases

MEROPSiM38.980.

Names & Taxonomyi

Protein namesi
Recommended name:
ImidazolonepropionaseUniRule annotation (EC:3.5.2.7UniRule annotation)
Alternative name(s):
Imidazolone-5-propionate hydrolaseUniRule annotation
Gene namesi
Name:hutIUniRule annotation
Ordered Locus Names:BBR47_42290
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
Proteomesi
  • UP000001877 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001338811 – 424ImidazolonepropionaseAdd BLAST424

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_42290.

Structurei

3D structure databases

ProteinModelPortaliC0ZHT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HutI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI2. Bacteria.
COG1228. LUCA.
HOGENOMiHOG000218460.
KOiK01468.
OMAiDHCTHLT.
OrthoDBiPOG091H0EIK.

Family and domain databases

CDDicd01296. Imidazolone-5PH. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_00372. HutI. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01224. hutI. 1 hit.

Sequencei

Sequence statusi: Complete.

C0ZHT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPVWIRHA SQLATLAGGS SSPVVGAKMN ELSIIEDGSI WLEDGVIQRV
60 70 80 90 100
GTDEDLALHY RDRTHEAQII DASGKLVTPG LIDPHTHLVH AGSRQNEFNM
110 120 130 140 150
RLNGATYMEI MNNGGGIHST TAATRAATHE ELFAQSKQRL DQFLLHGVTT
160 170 180 190 200
VEAKSGYGLT LEDELKQLEV AKQLNEAHPI DIVSTFMGAH AVPREYKENP
210 220 230 240 250
DAFVDMVIEE MIPEVARRKL AVFNDVFCER GVFTPEQSRR ILEAGVRHGL
260 270 280 290 300
LPKIHADEIE PYEGAELAAS VGAVSADHLL RASDKGIEQM AEAGVIAVLL
310 320 330 340 350
PGTAFFLMAE SANGRKMIDR GVAVAISTDC NPGSSPTVSL PLIMNLGCLK
360 370 380 390 400
MGMTPAEVLT AATINAAHAI RCAHEVGSLE VGKKADVTIF DVPDFMTLQY
410 420
RYGINHVNTV IKNGTIVVAE GRLA
Length:424
Mass (Da):45,811
Last modified:May 26, 2009 - v1
Checksum:iFAFBBECDF817321A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA. Translation: BAH45206.1.
RefSeqiWP_015892472.1. NC_012491.1.

Genome annotation databases

EnsemblBacteriaiBAH45206; BAH45206; BBR47_42290.
KEGGibbe:BBR47_42290.
PATRICi21238808. VBIBreBre96763_4196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA. Translation: BAH45206.1.
RefSeqiWP_015892472.1. NC_012491.1.

3D structure databases

ProteinModelPortaliC0ZHT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi358681.BBR47_42290.

Protein family/group databases

MEROPSiM38.980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH45206; BAH45206; BBR47_42290.
KEGGibbe:BBR47_42290.
PATRICi21238808. VBIBreBre96763_4196.

Phylogenomic databases

eggNOGiENOG4105CI2. Bacteria.
COG1228. LUCA.
HOGENOMiHOG000218460.
KOiK01468.
OMAiDHCTHLT.
OrthoDBiPOG091H0EIK.

Enzyme and pathway databases

UniPathwayiUPA00379; UER00551.

Family and domain databases

CDDicd01296. Imidazolone-5PH. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_00372. HutI. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01224. hutI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHUTI_BREBN
AccessioniPrimary (citable) accession number: C0ZHT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.