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C0ZFP5 (C0ZFP5_BREBN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabHA EMBL BAH44604.1
Synonyms:fabH2 HAMAP MF_01815
Ordered Locus Names:BBR47_36270
OrganismBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) [Complete proteome] [HAMAP]
Taxonomic identifier358681 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region257 – 2615ACP-binding By similarity HAMAP MF_01815

Sites

Active site1161 By similarity HAMAP MF_01815
Active site2561 By similarity HAMAP MF_01815
Active site2861 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
C0ZFP5 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 76B839466A711A68

FASTA33835,795
        10         20         30         40         50         60 
MSAKRSVGIL STGSYTPERV LTNFDLEKMV ETSDEWIVSR TGIRERRISS PEQASSDLAY 

        70         80         90        100        110        120 
EAAKAALEKA NISAEQLDMI IVATVTPDMS FPSTACLLQE KLGATRAAAM DLSAACTGFL 

       130        140        150        160        170        180 
YGITTATQFI QNGLYKKVLV VGVETLSKIT NYKDRNTCVL FGDGAGAAVI GEVTEGYGFQ 

       190        200        210        220        230        240 
SFELGADGSG GSLLCMPAGG SRTPASVESV EQGLHYLYMA GGEVFKFAVR VMNSATEAVL 

       250        260        270        280        290        300 
SKAGVSKDEI DLLVPHQANK RIIDSAVQRF GLSEDKVAIN LDRYGNMSSA SIPVALDEAV 

       310        320        330 
KAGRVKEGDN LILVGFGGGL TWGATLLKWC TTPAEGSK

« Hide

References

[1]"Brevibacillus brevis strain 47, complete genome."
Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H. expand/collapse author list , Udaka S., Tanikawa S., Fujita N.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008955 Genomic DNA. Translation: BAH44604.1.
RefSeqYP_002773108.1. NC_012491.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC0ZFP5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7719498.
GenomeReviewsGene locus BBR47_36270 in contig AP008955_GR.
KEGGbbe:BBR47_36270.
PATRIC21237552. VBIBreBre96763_3593.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAHTIFMEG.
ProtClustDBCLSK2547329.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0ZFP5_BREBN
AccessionPrimary (citable) accession number: C0ZFP5
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info