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C0ZF43

- PNP_BREBN

UniProt

C0ZF43 - PNP_BREBN

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, BBR47_34250
Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi491 – 4911Magnesium By similarity
Metal bindingi497 – 4971Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBBRE358681:GHYS-3556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:BBR47_34250
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
ProteomesiUP000001877: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000185724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_34250.

Structurei

3D structure databases

ProteinModelPortaliC0ZF43.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini558 – 61760KH
Add
BLAST
Domaini627 – 69569S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRRIITHD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0ZF43-1 [UniParc]FASTAAdd to Basket

« Hide

MEQQYRTYDF ELAGRKLTLE FGKMAKQAHG SVLVRYGDTA ILSAVTVSKE    50
PKPLDFFPLT VNYEERLYAV GKIPGGFIKR EGRPSEKAIL ASRLIDRPVR 100
PLFAEGFRND VQIVNTVLSV DQDCSPEIAA MIGTSAALCV SEIPFEGPIA 150
GVIVGRIDGE FVINPTVAQA EKSDIHLTVA GTHKAINMVE AAANQVPEAI 200
MLEAIMAGHD VIKQLVEFQN MIVSEIGKQK MEVILHEVDP EIDQAVRAYA 250
EARLKEAVRI EEKQARYDAI DDIKAETKEH FAAKDAEAYP EQEKMISEVL 300
GNIVKDEVRR LITDEKVRPD GRALNEIRPL SSETTILSRT HGSAMFTRGQ 350
TQALSVCTLG ALGDVQILDG LGLEESKRFM HHYNFPPYSV GEARPLRPPG 400
RREIGHGALG ERAIEPIIPS EVEFPYTIRL VSEVIESNGS TSQASICASV 450
LALMDAGVPI KAPVAGIAMG LIMSKDEKSF SILTDIQGME DHLGDMDFKV 500
AGTEAGVTAI QMDIKISGIN REILELALEQ ARVGRLHILN HMMSTISEPR 550
KELSPYAPKI MTMTINPEKI RDVIGPQGRV INKIIEETGV KIDIEQDGRV 600
FIASINHEAN LRAKQIIEDL VREVAVGQVY LGTVKRVEKY GAFIELFAGK 650
EGLCHISQLA EERVAKTEDV VAVGDKVQVK VTEIDDQGRV NLSRKAVLKE 700
QAAAEQAAET PTKAE 715
Length:715
Mass (Da):78,518
Last modified:May 26, 2009 - v1
Checksum:iC4205DC2656751F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH44402.1.
RefSeqiWP_015891706.1. NC_012491.1.
YP_002772906.1. NC_012491.1.

Genome annotation databases

EnsemblBacteriaiBAH44402; BAH44402; BBR47_34250.
GeneIDi7718940.
KEGGibbe:BBR47_34250.
PATRICi21237166. VBIBreBre96763_3400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH44402.1 .
RefSeqi WP_015891706.1. NC_012491.1.
YP_002772906.1. NC_012491.1.

3D structure databases

ProteinModelPortali C0ZF43.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 358681.BBR47_34250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH44402 ; BAH44402 ; BBR47_34250 .
GeneIDi 7718940.
KEGGi bbe:BBR47_34250.
PATRICi 21237166. VBIBreBre96763_3400.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi RRIITHD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BBRE358681:GHYS-3556-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Brevibacillus brevis strain 47, complete genome."
    Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
    , Udaka S., Tanikawa S., Fujita N.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 47 / JCM 6285 / NBRC 100599.

Entry informationi

Entry nameiPNP_BREBN
AccessioniPrimary (citable) accession number: C0ZF43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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