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C0ZDU5

- ACDH_BREBN

UniProt

C0ZDU5 - ACDH_BREBN

Protein

Acetaldehyde dehydrogenase

Gene

BBR47_29770

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei127 – 1271Acyl-thioester intermediateUniRule annotation
    Binding sitei269 – 2691NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi158 – 1669NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBBRE358681:GHYS-3105-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:BBR47_29770
    OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
    Taxonomic identifieri358681 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
    ProteomesiUP000001877: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Acetaldehyde dehydrogenasePRO_0000387628Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi358681.BBR47_29770.

    Structurei

    3D structure databases

    ProteinModelPortaliC0ZDU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiIPEDADH.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C0ZDU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKVKVAILG SGNIGTDLMI KLGRSPILEL TSMIGIDPDS DGLRRAKAAG    50
    YYVFDGGLQP FLESGAELAD IVFDATSAKA HILHAKALRE AGKFAIDLTP 100
    AAVGPYVVPS VNLGAHLNET NINLITCGGQ ATIPIVHAIG SVSPVSYAEI 150
    VATISSKSAG PGTRSNIDEF TETTAQGIEA IGGAKKGKAI IILNPAEPPI 200
    LMRDTVYAVV DEGADRQAIV KAIHQTVAYI QSYVPGYRLR SEPIFDENKI 250
    TVFFEVEGAG NYLPTYSGNL DIMTATAVKV AEEYAKYVVG IGTSM 295
    Length:295
    Mass (Da):31,126
    Last modified:May 26, 2009 - v1
    Checksum:iEA89A33055B6278A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH43954.1.
    RefSeqiWP_015891272.1. NC_012491.1.
    YP_002772458.1. NC_012491.1.

    Genome annotation databases

    EnsemblBacteriaiBAH43954; BAH43954; BBR47_29770.
    GeneIDi7715626.
    KEGGibbe:BBR47_29770.
    PATRICi21236290. VBIBreBre96763_2965.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH43954.1 .
    RefSeqi WP_015891272.1. NC_012491.1.
    YP_002772458.1. NC_012491.1.

    3D structure databases

    ProteinModelPortali C0ZDU5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 358681.BBR47_29770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH43954 ; BAH43954 ; BBR47_29770 .
    GeneIDi 7715626.
    KEGGi bbe:BBR47_29770.
    PATRICi 21236290. VBIBreBre96763_2965.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi IPEDADH.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci BBRE358681:GHYS-3105-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Brevibacillus brevis strain 47, complete genome."
      Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
      , Udaka S., Tanikawa S., Fujita N.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 47 / JCM 6285 / NBRC 100599.

    Entry informationi

    Entry nameiACDH_BREBN
    AccessioniPrimary (citable) accession number: C0ZDU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3