C0ZCE7 (HIS8_BREBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	BBR47_24790

Organism

Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) [Complete proteome] [HAMAP]

Taxonomic identifier

358681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000149083
Amino acid modifications
	Modified residue	222	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	C0ZCE7 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: F6152D20D028E527	FASTA	364	40,332
	10 20 30 40 50 60 MQPKQRILNA PVYQPGKPID DVKREFGLTE VIKLASNENP FGSSPKAKAA ISEQLDNLAL 70 80 90 100 110 120 YPDGASLNLR WDLADFLGVK PSQLFFGNGS DEILLMISRA FLSEGTNAVM ATQTFSQYRS 130 140 150 160 170 180 NGIIEGADLI EVPLKDGVHD LEAMAAAINE QTKVVWVCNP NNPSGTIVTT SELEAFMKKT 190 200 210 220 230 240 PKDVLVVLDE AYYEYVVDPE YPQTVPMLAE YPNLIILRTF SKIYGLAALR IGYGIASEEL 250 260 270 280 290 300 ISSLEHVREP FNTGTLGQVA ARAALKDQEF VKSCRDRNRE GMKQFTDSFD EWGLSYYPSQ 310 320 330 340 350 360 TNFILVDLKM DSDEVFKKLL SQGIIVRSGN ALGFPGFQRI TIGTKEQNDK ILSVLKEIVT GALK

References

[1]

"Brevibacillus brevis strain 47, complete genome." Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H. , Udaka S., Tanikawa S., Fujita N. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 47 / JCM 6285 / NBRC 100599.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008955 Genomic DNA. Translation: BAH43456.1.
RefSeq	YP_002771960.1. NC_012491.1.
3D structure databases
ProteinModelPortal	C0ZCE7.
ModBase	Search...
Protein-protein interaction databases
STRING	C0ZCE7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7720758.
GenomeReviews	Gene locus BBR47_24790 in contig AP008955_GR.
KEGG	bbe:BBR47_24790.
PATRIC	21235280. VBIBreBre96763_2463.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YIELADI.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_BREBN

Accession

Primary (citable) accession number: C0ZCE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program