C0ZC50 (DEOB_BREBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopentomutase
EC=5.4.2.7

Alternative name(s):
Phosphodeoxyribomutase

Gene names

Name:	deoB
Ordered Locus Names:	BBR47_23820

Organism

Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) [Complete proteome] [HAMAP]

Taxonomic identifier

358681 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Brevibacillus › Brevibacillus brevis

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphotransfer between the C1 and C5 carbon atoms of pentose By similarity. HAMAP-Rule MF_00740
Catalytic activity	Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate. HAMAP-Rule MF_00740 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate. HAMAP-Rule MF_00740
Cofactor	Binds 1 or 2 manganese ions Potential.
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3. HAMAP-Rule MF_00740
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphopentomutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cellular metabolic compound salvage Inferred from electronic annotation. Source: InterPro deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: HAMAP phosphopentomutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Phosphopentomutase HAMAP-Rule MF_00740		PRO_1000189774
Sites
	Metal binding	12	1	Manganese By similarity
	Metal binding	290	1	Manganese By similarity
	Metal binding	326	1	Manganese By similarity
	Metal binding	327	1	Manganese By similarity
	Metal binding	338	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	C0ZC50 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: AEE3DCEB7233FED3	FASTA	390	42,784
	10 20 30 40 50 60 MQYSRVFLIV MDSVGIGEQP DAPKFNDAGA NTLGHIAERV AGFSLPNLQK LGLGNIAPLK 70 80 90 100 110 120 NVEPVAAPMA HYGKMQEISM GKDTTTGHWE IMGLHVSTPF NTYPDGFPQE LISEFEQRIG 130 140 150 160 170 180 RKVLGNKVAS GTDILDELGE EHMKTGAVIV YTSADSVFQV AAHEEIVPLE ELYHICEVAR 190 200 210 220 230 240 ELTLRDEFAV TRVIARPFLG QPGNFSRTAN RHDYSVKPFA PTVMNRLQDA GLSSIAIGKI 250 260 270 280 290 300 SDIYAEEGVT QSIRTKDNMD GVDQILGTMK QSFTGLSFVN LVDFDAKFGH RRDPEGYGQA 310 320 330 340 350 360 LMEFDARIPE LLEALQENDL LVITADHGND PVHHGSDHTR EYVPLLAYHK GIQAGQHLGI 370 380 390 RETFADLGAT IADNFGVTAP VIGKSFLNRL

References

[1]

"Brevibacillus brevis strain 47, complete genome." Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H. , Udaka S., Tanikawa S., Fujita N. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 47 / JCM 6285 / NBRC 100599.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008955 Genomic DNA. Translation: BAH43359.1.
RefSeq	YP_002771863.1. NC_012491.1.
3D structure databases
ProteinModelPortal	C0ZC50.
ModBase	Search...
Protein-protein interaction databases
STRING	358681.BBR47_23820.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAH43359; BAH43359; BBR47_23820.
GeneID	7720405.
KEGG	bbe:BBR47_23820.
PATRIC	21235086. VBIBreBre96763_2367.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1015.
HOGENOM	HOG000008159.
KO	K01839.
OMA	PNMAKLG.
Enzyme and pathway databases
BioCyc	BBRE358681:GHYS-4801-MONOMER.
UniPathway	UPA00087; UER00173.
Family and domain databases
Gene3D	3.30.70.1250. 1 hit. 3.40.720.10. 2 hits.
HAMAP	MF_00740. Phosphopentomut.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR010045. DeoB. IPR006124. Metalloenzyme. IPR024052. Phosphopentomutase_DeoB_cap. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001491. Ppentomutase. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF143856. SSF143856. 1 hit.
TIGRFAMs	TIGR01696. deoB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOB_BREBN

Accession

Primary (citable) accession number: C0ZC50

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program