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C0ZBW6

- GCSPA_BREBN

UniProt

C0ZBW6 - GCSPA_BREBN

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, BBR47_22980
Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBBRE358681:GHYS-2422-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:BBR47_22980
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
ProteomesiUP000001877: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000147979Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi358681.BBR47_22980.

Structurei

3D structure databases

ProteinModelPortaliC0ZBW6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C0ZBW6-1 [UniParc]FASTAAdd to Basket

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MKYRYLPQTD QDKREMLETL GISSVEELFA DIPEEVRFKG ALNIPEALSE    50
PDLVKYFTHL ANKNVNFSTH VNFLGAGVYQ HYTPSTVNHM LLRGEFFTAY 100
TPYQPEISQG ELQAIFEFQT MVCELTGMEV ANSSMYDGAT SLAEAAMMAA 150
GHTGKKRVIV SRAVHPEARG VLKTYAYGQN VELVEVGINS DGVTDTAALE 200
ALVDENTAAI IVQYPNFFGN VEDLGAIETI AHGKGALLIT SSNPLALGVL 250
EAPGKLGADI VVGDMQPFGI PASFGGPHCG YFATTTKLMR KMPGRIVGQT 300
KDENGKRGFV LTLQAREQHI RREKATSNIC SNQALLALAA SIAMTALGKQ 350
GVQEMAMMNL QKAHYAKNAL QAKGLEIVFT SPFFNEFVVK LNKPVAEVNK 400
GLLAAGIIGG YDLGLDYPEF ANHTLLAVTE LRTKEEIDIL AAELEAITRA 450
Length:450
Mass (Da):48,870
Last modified:May 26, 2009 - v1
Checksum:iE2DE32D128E0745E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH43275.1.
RefSeqiYP_002771779.1. NC_012491.1.

Genome annotation databases

EnsemblBacteriaiBAH43275; BAH43275; BBR47_22980.
GeneIDi7719592.
KEGGibbe:BBR47_22980.
PATRICi21234918. VBIBreBre96763_2283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH43275.1 .
RefSeqi YP_002771779.1. NC_012491.1.

3D structure databases

ProteinModelPortali C0ZBW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 358681.BBR47_22980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH43275 ; BAH43275 ; BBR47_22980 .
GeneIDi 7719592.
KEGGi bbe:BBR47_22980.
PATRICi 21234918. VBIBreBre96763_2283.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci BBRE358681:GHYS-2422-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Brevibacillus brevis strain 47, complete genome."
    Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
    , Udaka S., Tanikawa S., Fujita N.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 47 / JCM 6285 / NBRC 100599.

Entry informationi

Entry nameiGCSPA_BREBN
AccessioniPrimary (citable) accession number: C0ZBW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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