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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBRE358681:G1G2J-2097-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BBR47_19950
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
Proteomesi
  • UP000001877 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001991841 – 805Leucine--tRNA ligaseAdd BLAST805

Proteomic databases

PRIDEiC0ZB13

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_19950

Structurei

3D structure databases

ProteinModelPortaliC0ZB13
SMRiC0ZB13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

C0ZB13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSHRNVEK KWQQYWEQNK TFKTSEDEGK KKFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LSRMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT
110 120 130 140 150
EHNINTFRRQ IKSLGFSYDW DREINTTDPH YYKWTQWIFT KLYEHGLAYI
160 170 180 190 200
DEVAVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMKQW VLKITAYAER
210 220 230 240 250
LLADLDELDW PESIKEMQRN WIGRSEGAEV TFGIEGHDES FTVFTTRPDT
260 270 280 290 300
LYGATYAVLA PEHKLVEQIT VPAQKEAVEA YLDQAKRKSD LERTDLAKEK
310 320 330 340 350
TGVFTGAYAI NPVNGERLPI WIADYVLISY GTGSIMAVPA HDERDYEFAK
360 370 380 390 400
TFDLPIKQVI AGGDISKEAY AGDGEHINSG MLDGLNKEQA ISKMIEWLEA
410 420 430 440 450
EGKGNRKVTY RLRDWLFSRQ RYWGEPIPIL HLEDGTMKVV PESELPIMLP
460 470 480 490 500
KTKEIKPSGT GESPLANIAE WVNTIDPETG MKARRETNTM PQWAGSCWYF
510 520 530 540 550
LRFIDPHNDK ALADPDKLKE WLPIDIYIGG AEHAVLHLLY SRFWHKFLYD
560 570 580 590 600
IGVVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI IDSHGADTLR
610 620 630 640 650
MYEMFMGPLD ASIAWSTKGL DGARRFLDRV YRLFVGDNGE LNEKIVETSN
660 670 680 690 700
VAGMERVYHQ TVKKVTEDYE GLRFNTGISQ LMVFVNEAYK AEVLPKKFME
710 720 730 740 750
DFVKMLSPIA PHLGEELWEK LGHSESVAYA AWPTYDEAKL VEDEVEIVLQ
760 770 780 790 800
INGKNKEKLL IASDSTKEQM EEMAKNNEMI NELIEGKTIV KVIAVPGKLV

NIVVR
Length:805
Mass (Da):91,900
Last modified:May 26, 2009 - v1
Checksum:iE593FEFD1648CE92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA Translation: BAH42972.1
RefSeqiWP_012685706.1, NC_012491.1

Genome annotation databases

EnsemblBacteriaiBAH42972; BAH42972; BBR47_19950
GeneIDi29259305
KEGGibbe:BBR47_19950

Similar proteinsi

Entry informationi

Entry nameiSYL_BREBN
AccessioniPrimary (citable) accession number: C0ZB13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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