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C0ZB13

- SYL_BREBN

UniProt

C0ZB13 - SYL_BREBN

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Protein
Leucine--tRNA ligase
Gene
leuS, BBR47_19950
Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBRE358681:GHYS-2108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BBR47_19950
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
ProteomesiUP000001877: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotation
PRO_1000199184Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_19950.

Structurei

3D structure databases

ProteinModelPortaliC0ZB13.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0ZB13-1 [UniParc]FASTAAdd to Basket

« Hide

MVFSHRNVEK KWQQYWEQNK TFKTSEDEGK KKFYALDMFP YPSGAGLHVG    50
HPEGYTATDI LSRMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT 100
EHNINTFRRQ IKSLGFSYDW DREINTTDPH YYKWTQWIFT KLYEHGLAYI 150
DEVAVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMKQW VLKITAYAER 200
LLADLDELDW PESIKEMQRN WIGRSEGAEV TFGIEGHDES FTVFTTRPDT 250
LYGATYAVLA PEHKLVEQIT VPAQKEAVEA YLDQAKRKSD LERTDLAKEK 300
TGVFTGAYAI NPVNGERLPI WIADYVLISY GTGSIMAVPA HDERDYEFAK 350
TFDLPIKQVI AGGDISKEAY AGDGEHINSG MLDGLNKEQA ISKMIEWLEA 400
EGKGNRKVTY RLRDWLFSRQ RYWGEPIPIL HLEDGTMKVV PESELPIMLP 450
KTKEIKPSGT GESPLANIAE WVNTIDPETG MKARRETNTM PQWAGSCWYF 500
LRFIDPHNDK ALADPDKLKE WLPIDIYIGG AEHAVLHLLY SRFWHKFLYD 550
IGVVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI IDSHGADTLR 600
MYEMFMGPLD ASIAWSTKGL DGARRFLDRV YRLFVGDNGE LNEKIVETSN 650
VAGMERVYHQ TVKKVTEDYE GLRFNTGISQ LMVFVNEAYK AEVLPKKFME 700
DFVKMLSPIA PHLGEELWEK LGHSESVAYA AWPTYDEAKL VEDEVEIVLQ 750
INGKNKEKLL IASDSTKEQM EEMAKNNEMI NELIEGKTIV KVIAVPGKLV 800
NIVVR 805
Length:805
Mass (Da):91,900
Last modified:May 26, 2009 - v1
Checksum:iE593FEFD1648CE92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH42972.1.
RefSeqiYP_002771476.1. NC_012491.1.

Genome annotation databases

EnsemblBacteriaiBAH42972; BAH42972; BBR47_19950.
GeneIDi7720245.
KEGGibbe:BBR47_19950.
PATRICi21234294. VBIBreBre96763_1981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008955 Genomic DNA. Translation: BAH42972.1 .
RefSeqi YP_002771476.1. NC_012491.1.

3D structure databases

ProteinModelPortali C0ZB13.
ModBasei Search...

Protein-protein interaction databases

STRINGi 358681.BBR47_19950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH42972 ; BAH42972 ; BBR47_19950 .
GeneIDi 7720245.
KEGGi bbe:BBR47_19950.
PATRICi 21234294. VBIBreBre96763_1981.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BBRE358681:GHYS-2108-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Brevibacillus brevis strain 47, complete genome."
    Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
    , Udaka S., Tanikawa S., Fujita N.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 47 / JCM 6285 / NBRC 100599.

Entry informationi

Entry nameiSYL_BREBN
AccessioniPrimary (citable) accession number: C0ZB13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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