C0ZB07 (AROE_BREBN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BBR47_19890

Organism

Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) [Complete proteome] [HAMAP]

Taxonomic identifier

358681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000124875
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	C0ZB07 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: C0BFD2F070CC90EF	FASTA	283	30,245
	10 20 30 40 50 60 MITSKTQLVG LFGHPVSHSQ SPMMHNTAFL ETGLGFAYAA FDVEPENLED AVAGIRALGL 70 80 90 100 110 120 KGINVTIPHK VAIMPMLDEI DPLAKRIGAV NTVVSRDGRL IGYNTDGMGY VRSLVEETGI 130 140 150 160 170 180 VLEKQVVTMV GAGGAARAVA FTLAEQGVKE IRIINRSRER AAVLAEHVGM IVPTKIVEQG 190 200 210 220 230 240 EGEAAIADSS LLINTTSIGM LPNVQETPVP AEWLHSGLTV SDLIYNPLET RLLKEARAIG 250 260 270 280 ATVHSGIGMF VNQGALAFEL WTGEQAPTGV MREVVLQQLK KTT

References

[1]

"Brevibacillus brevis strain 47, complete genome." Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H. , Udaka S., Tanikawa S., Fujita N. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 47 / JCM 6285 / NBRC 100599.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008955 Genomic DNA. Translation: BAH42966.1.
RefSeq	YP_002771470.1. NC_012491.1.
3D structure databases
ProteinModelPortal	C0ZB07.
ModBase	Search...
Protein-protein interaction databases
STRING	C0ZB07.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7720475.
GenomeReviews	Gene locus BBR47_19890 in contig AP008955_GR.
KEGG	bbe:BBR47_19890.
PATRIC	21234282. VBIBreBre96763_1975.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TIFNITE.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BREBN

Accession

Primary (citable) accession number: C0ZB07

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program