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C0ZAJ5 (C0ZAJ5_BREBN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP-Rule MF_01815
EC=2.3.1.180 HAMAP-Rule MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP-Rule MF_01815
Beta-ketoacyl-ACP synthase III HAMAP-Rule MF_01815
Gene names
Name:fabHB EMBL BAH42804.1
Synonyms:fabH HAMAP-Rule MF_01815
Ordered Locus Names:BBR47_18270
OrganismBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) [Complete proteome] [HAMAP]
Taxonomic identifier358681 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Brevibacillus ›

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP-Rule MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP-Rule MF_01815 SAAS SAAS004655

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP-Rule MF_01815 SAAS SAAS004655

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01815 SAAS SAAS004655

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01815 SAAS SAAS004655.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP-Rule MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP-Rule MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region257 – 2615ACP-binding By similarity HAMAP-Rule MF_01815

Sites

Active site1191 By similarity HAMAP-Rule MF_01815
Active site2561 By similarity HAMAP-Rule MF_01815
Active site2861 By similarity HAMAP-Rule MF_01815

Sequences

Sequence LengthMass (Da)Tools
C0ZAJ5 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 378FBF35B6D02E79

FASTA33135,882
        10         20         30         40         50         60 
MMTNTSPFKS RITAIGTYVP SRVLTNTDME KLVDTSNEWI LQRTGIHERR MAREDEFTSD 

        70         80         90        100        110        120 
LAIAAIHDMI ANYGKDVRDV DMILVATSTP DYPFPSVASQ IQAHFQVEQA GAMDLSATCA 

       130        140        150        160        170        180 
GFTYALHTAN ALISSGLHRK VLVVGAETLT KVTDYTDRTT CILFGDGAGA VLVEQDSTAP 

       190        200        210        220        230        240 
GFLSVYLGSK GDGGIHVYRA GLSTRMDGRE LSGNGCMVQN GREVYKWAVT TVPKGMLEVV 

       250        260        270        280        290        300 
NRAGKTLEDV DWFIPHSANL RMIESICEKS QFPLDKTLYS LTHYGNTSSA TIPLSLALGI 

       310        320        330 
KEGKVKAGDT ILVYGFGGGL VHGGLLFTWN P

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References

[1]"Brevibacillus brevis strain 47, complete genome."
Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H. expand/collapse author list , Udaka S., Tanikawa S., Fujita N.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 47 / JCM 6285 / NBRC 100599.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008955 Genomic DNA. Translation: BAH42804.1.
RefSeqYP_002771308.1. NC_012491.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING358681.BBR47_18270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH42804; BAH42804; BBR47_18270.
GeneID7721426.
KEGGbbe:BBR47_18270.
PATRIC21233968. VBIBreBre96763_1818.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHOG000246674.
KOK00648.
OMADWFVPHS.
ProtClustDBPRK12879.

Enzyme and pathway databases

BioCycBBRE358681:GHYS-4858-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
HAMAPMF_01815. FabH.
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. fabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC0ZAJ5_BREBN
AccessionPrimary (citable) accession number: C0ZAJ5
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info