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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBBRE358681:GHYS-5632-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:BBR47_54590
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
Proteomesi
  • UP000001877 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Malonyl-[acyl-carrier protein] O-methyltransferasePRO_0000412487Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_54590.

Structurei

3D structure databases

ProteinModelPortaliC0Z787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082K6. Bacteria.
ENOG4111P8N. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiICEQALV.
OrthoDBiPOG091H05JY.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.

Sequencei

Sequence statusi: Complete.

C0Z787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKRAISSRF SEKAVSYEKY ALVQKKMADH LSQMVTEITN ENDVRSILEI
60 70 80 90 100
GCGTGGLTRV IRSYFSAAHY EAVEIAQGML EQAKNNLEQH GLICSFSQAD
110 120 130 140 150
AEEWVWEQQA KSKDLIVSGA CFQWFARPAH TLRGLARILK PGAPLVFSTF
160 170 180 190 200
GPDTFWELHD SFTNAHAILG EKGVRHGLEF LSARDWHEQL EQAGFTDIEI
210 220 230 240 250
SRKYERLTYP GVRDFLHAVK AVGASVSMEQ GSGLGRRKLL AEMIRYYEQT
260 270
YKRETGIPVT YEVIYVRAVS SRAVTFFK
Length:278
Mass (Da):31,482
Last modified:May 26, 2009 - v1
Checksum:i33965D0DBC772364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA. Translation: BAH46436.1.
RefSeqiWP_015893629.1. NC_012491.1.

Genome annotation databases

EnsemblBacteriaiBAH46436; BAH46436; BBR47_54590.
KEGGibbe:BBR47_54590.
PATRICi21241240. VBIBreBre96763_5395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA. Translation: BAH46436.1.
RefSeqiWP_015893629.1. NC_012491.1.

3D structure databases

ProteinModelPortaliC0Z787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi358681.BBR47_54590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH46436; BAH46436; BBR47_54590.
KEGGibbe:BBR47_54590.
PATRICi21241240. VBIBreBre96763_5395.

Phylogenomic databases

eggNOGiENOG41082K6. Bacteria.
ENOG4111P8N. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiICEQALV.
OrthoDBiPOG091H05JY.

Enzyme and pathway databases

UniPathwayiUPA00078.
BioCyciBBRE358681:GHYS-5632-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBIOC_BREBN
AccessioniPrimary (citable) accession number: C0Z787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 26, 2009
Last modified: September 7, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.