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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processBiotin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBBRE358681:G1G2J-5568-MONOMER
UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:BBR47_54590
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
Proteomesi
  • UP000001877 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004124871 – 278Malonyl-[acyl-carrier protein] O-methyltransferaseAdd BLAST278

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_54590

Structurei

3D structure databases

ProteinModelPortaliC0Z787
SMRiC0Z787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082K6 Bacteria
ENOG4111P8N LUCA
HOGENOMiHOG000265010
KOiK02169
OMAiWAICYSK
OrthoDBiPOG091H05JY

Family and domain databases

HAMAPiMF_00835 BioC, 1 hit
InterProiView protein in InterPro
IPR011814 BioC
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02072 BioC, 1 hit

Sequencei

Sequence statusi: Complete.

C0Z787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKRAISSRF SEKAVSYEKY ALVQKKMADH LSQMVTEITN ENDVRSILEI
60 70 80 90 100
GCGTGGLTRV IRSYFSAAHY EAVEIAQGML EQAKNNLEQH GLICSFSQAD
110 120 130 140 150
AEEWVWEQQA KSKDLIVSGA CFQWFARPAH TLRGLARILK PGAPLVFSTF
160 170 180 190 200
GPDTFWELHD SFTNAHAILG EKGVRHGLEF LSARDWHEQL EQAGFTDIEI
210 220 230 240 250
SRKYERLTYP GVRDFLHAVK AVGASVSMEQ GSGLGRRKLL AEMIRYYEQT
260 270
YKRETGIPVT YEVIYVRAVS SRAVTFFK
Length:278
Mass (Da):31,482
Last modified:May 26, 2009 - v1
Checksum:i33965D0DBC772364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA Translation: BAH46436.1
RefSeqiWP_015893629.1, NC_012491.1

Genome annotation databases

EnsemblBacteriaiBAH46436; BAH46436; BBR47_54590
GeneIDi29262679
KEGGibbe:BBR47_54590

Similar proteinsi

Entry informationi

Entry nameiBIOC_BREBN
AccessioniPrimary (citable) accession number: C0Z787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 26, 2009
Last modified: April 25, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health