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C0Z6S0

- ASSY_BREBN

UniProt

C0Z6S0 - ASSY_BREBN

Protein

Argininosuccinate synthase

Gene

argG

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871CitrullineUniRule annotation
    Binding sitei117 – 1171ATP; via amide nitrogenUniRule annotation
    Binding sitei119 – 1191AspartateUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei123 – 1231CitrullineUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei127 – 1271CitrullineUniRule annotation
    Binding sitei175 – 1751CitrullineUniRule annotation
    Binding sitei184 – 1841CitrullineUniRule annotation
    Binding sitei260 – 2601CitrullineUniRule annotation
    Binding sitei272 – 2721CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 179ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBRE358681:GHYS-5464-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:BBR47_52920
    OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
    Taxonomic identifieri358681 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
    ProteomesiUP000001877: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Argininosuccinate synthasePRO_1000191883Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi358681.BBR47_52920.

    Structurei

    3D structure databases

    ProteinModelPortaliC0Z6S0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiDIAHENE.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0Z6S0-1 [UniParc]FASTAAdd to Basket

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    MAKDKIVLAY SGGLDTSVAI KWLQDTYNYD VIAVALDVGE GKDLDFVQKK    50
    ALQVGALKSI VVDAKDAFAE EFVLPALKAN AMYEGKYPLV SALSRYLISR 100
    VLVEIAEKEG AVAVAHGCTG KGNDQVRFDV SFTALNPDIK IVAPVREWGW 150
    TRDEEIEYAK KNNIPIPIDL DNPYSIDQNL WGRSCECGVL EDPWAAPPEG 200
    AYDLTKSIMD APDEAEEIEI TFVQGKPTAL NGEELPLAEL ILKLNKIAGN 250
    HGVGRIDHVE NRLVGIKSRE VYETPAATTL ILAHRELEFL TQPREVAQFK 300
    PIVEQKLAQV IYEGLWFSPI RNAVQAFIEE TQKHVTGVVR VKLHKGHAIV 350
    VGRTSASSLY SHELATYNAG DQFDHKAALG FIKLWGLPTK VYAQVNEGVL 400
    HENKNTAIKI LDEKDAIKQ 419
    Length:419
    Mass (Da):46,325
    Last modified:May 26, 2009 - v1
    Checksum:iB0A5A91165E07C47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH46269.1.
    RefSeqiYP_002774773.1. NC_012491.1.

    Genome annotation databases

    EnsemblBacteriaiBAH46269; BAH46269; BBR47_52920.
    GeneIDi7716889.
    KEGGibbe:BBR47_52920.
    PATRICi21240916. VBIBreBre96763_5233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008955 Genomic DNA. Translation: BAH46269.1 .
    RefSeqi YP_002774773.1. NC_012491.1.

    3D structure databases

    ProteinModelPortali C0Z6S0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 358681.BBR47_52920.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH46269 ; BAH46269 ; BBR47_52920 .
    GeneIDi 7716889.
    KEGGi bbe:BBR47_52920.
    PATRICi 21240916. VBIBreBre96763_5233.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi DIAHENE.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci BBRE358681:GHYS-5464-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brevibacillus brevis strain 47, complete genome."
      Hosoyama A., Yamada R., Hongo Y., Terui Y., Ankai A., Masuyama W., Sekiguchi M., Takeda T., Asano K., Ohji S., Ichikawa N., Narita S., Aoki N., Miura H., Matsushita S., Sekigawa T., Yamagata H., Yoshikawa H.
      , Udaka S., Tanikawa S., Fujita N.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 47 / JCM 6285 / NBRC 100599.

    Entry informationi

    Entry nameiASSY_BREBN
    AccessioniPrimary (citable) accession number: C0Z6S0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3