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C0Z0P8

- C0Z0P8_LACRE

UniProt

C0Z0P8 - C0Z0P8_LACRE

Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Lactobacillus reuteri MM2-3
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

    Catalytic activityi

    UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
    Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
    Gene namesi
    Name:mraYUniRule annotationImported
    ORF Names:HMPREF0535_1613Imported
    OrganismiLactobacillus reuteri MM2-3Imported
    Taxonomic identifieri585517 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliC0Z0P8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical;UniRule annotationAdd
    BLAST
    Transmembranei61 – 8121Helical;UniRule annotationAdd
    BLAST
    Transmembranei98 – 11821Helical;UniRule annotationAdd
    BLAST
    Transmembranei120 – 14021Helical;UniRule annotationAdd
    BLAST
    Transmembranei153 – 17321Helical;UniRule annotationAdd
    BLAST
    Transmembranei176 – 19621Helical;UniRule annotationAdd
    BLAST
    Transmembranei205 – 22723Helical;UniRule annotationAdd
    BLAST
    Transmembranei231 – 25323Helical;UniRule annotationAdd
    BLAST
    Transmembranei282 – 30221Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    OrthoDBiEOG69GZPZ.

    Family and domain databases

    HAMAPiMF_00038. MraY.
    InterProiIPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view]
    PANTHERiPTHR22926. PTHR22926. 1 hit.
    PfamiPF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00445. mraY. 1 hit.
    PROSITEiPS01347. MRAY_1. 1 hit.
    PS01348. MRAY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C0Z0P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSLIKYFRA KKEGQQIRKE GPTWHAKKAG TPTMGGLLFI FSAVVTILWV    50
    AAWQGLITNT LWALLFVLVV YGLIGMWDDS IKIFHHQNEG FKPWQKALCQ 100
    VLAAMVFTVI YQHEGFQMGF GTTQIGWLYG LFIIFWIVGF SNAVNLTDGL 150
    DGLVSGLSII SFAAYLIIAL VNLNQPGYPE IALFCLAMIG TLLGFFPYNH 200
    KPAKIFMGDM GSLAIGASLA AVSLLLHHEW SLLVIGIVYV CETASVILQV 250
    ASFKTTGKRI FKMTPIHHHF EMSGWSEWKI DIVFWLVGLV AAIIAVTTIL 300
    LVG 303
    Length:303
    Mass (Da):33,569
    Last modified:May 26, 2009 - v1
    Checksum:i702E9CDF428CEAA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACLB01000090 Genomic DNA. Translation: EEI08559.1.

    Genome annotation databases

    EnsemblBacteriaiEEI08559; EEI08559; HMPREF0535_1613.
    PATRICi37024688. VBILacReu127513_1232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACLB01000090 Genomic DNA. Translation: EEI08559.1 .

    3D structure databases

    ProteinModelPortali C0Z0P8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEI08559 ; EEI08559 ; HMPREF0535_1613 .
    PATRICi 37024688. VBILacReu127513_1232.

    Phylogenomic databases

    OrthoDBi EOG69GZPZ.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    HAMAPi MF_00038. MraY.
    InterProi IPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view ]
    PANTHERi PTHR22926. PTHR22926. 1 hit.
    Pfami PF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00445. mraY. 1 hit.
    PROSITEi PS01347. MRAY_1. 1 hit.
    PS01348. MRAY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MM2-3Imported.

    Entry informationi

    Entry nameiC0Z0P8_LACRE
    AccessioniPrimary (citable) accession number: C0Z0P8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    External Data

    Dasty 3