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C0XXH6 (C0XXH6_BURPS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-threonine 3-dehydrogenase HAMAP MF_00627
EC=1.1.1.103 HAMAP MF_00627
Gene names
Name:tdh HAMAP MF_00627 EMBL EEH30410.1
ORF Names:BUH_4251 EMBL EEH30410.1
OrganismBurkholderia pseudomallei Pakistan 9 EMBL EEH30410.1
Taxonomic identifier595498 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627 SAAS SAAS002328

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00627 SAAS SAAS002328

Pathway

Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627 SAAS SAAS002328

Subunit structure

Homotetramer By similarity. HAMAP MF_00627

Subcellular location

Cytoplasm By similarity HAMAP MF_00627 SAAS SAAS002328.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. HAMAP MF_00627 RuleBase RU000468

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding381Zinc 1; catalytic By similarity HAMAP MF_00627
Metal binding631Zinc 1; catalytic By similarity HAMAP MF_00627
Metal binding931Zinc 2 By similarity HAMAP MF_00627
Metal binding961Zinc 2 By similarity HAMAP MF_00627
Metal binding991Zinc 2 By similarity HAMAP MF_00627
Metal binding1071Zinc 2 By similarity HAMAP MF_00627
Metal binding1481Zinc 1; catalytic By similarity HAMAP MF_00627

Sequences

Sequence LengthMass (Da)Tools
C0XXH6 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 7B68D10DE57B44E7

FASTA34337,461
        10         20         30         40         50         60 
MKALAKLERG PGLTLTRVKK PEVGHNDVLI KIRRTAICGT DIHIWKWDDW AQKTIPVPMH 

        70         80         90        100        110        120 
VGHEYVGEIV EMGQEVRGFS IGDRVSGEGH ITCGFCRNCR AGRRHLCRNT VGVGVNREGA 

       130        140        150        160        170        180 
FAEYLAIPAF NAFKIPPEIS DDLAAIFDPF GNATHTALSF NLVGEDVLIT GAGPIGVMAV 

       190        200        210        220        230        240 
AIAKHVGARN VVITDINDYR LELARKMGAT RAVNVSRESL RDVMADLHMT EGFDVGLEMS 

       250        260        270        280        290        300 
GVPSAFTSLL ESMNHGGKVA LLGIPPAQTA IDWNQVIFKG LEIKGIYGRE MFETWYKMVA 

       310        320        330        340 
MLQSGLDLSP IITHRFAVDD YEKGFAAMLS GESGKVILDW ADA

« Hide

References

[1]Harkins D.M., Brinkac L.M., Rogers Y.C., Detter J.C., Munk A.C., Bruce D.C., Sims D.R., Brettin T.S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Pakistan 9 EMBL EEH30410.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ACKA01000009 Genomic DNA. Translation: EEH30410.1.

3D structure databases

ProteinModelPortalC0XXH6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC27908124. VBIBurPse53205_0687.

Phylogenomic databases

OMAMMRSGMS.

Family and domain databases

HAMAPMF_00627. Thr_dehydrog.
[Tree]
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR004627. L-Threonine_3-DHase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
TIGRFAMsTIGR00692. Tdh. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC0XXH6_BURPS
AccessionPrimary (citable) accession number: C0XXH6
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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