C0SX92 (C0SX92_BORBU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipoprotein signal peptidase HAMAP MF_00161 RuleBase RU000594
EC=3.4.23.36 HAMAP MF_00161 RuleBase RU000594

Alternative name(s):
Prolipoprotein signal peptidase HAMAP MF_00161
Signal peptidase II HAMAP MF_00161

Gene names

Name:	lspA HAMAP MF_00161 EMBL EEH31722.1
ORF Names:	BBUBOL26_0479 EMBL EEH31722.1

Organism

Borrelia burgdorferi Bol26 EMBL EEH31722.1

Taxonomic identifier

445984 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161 RuleBase RU000594 SAAS SAAS001872
Catalytic activity	Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161 RuleBase RU000594 SAAS SAAS001872
Pathway	Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161 SAAS SAAS001872
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.
Sequence similarities	Belongs to the peptidase A8 family. HAMAP MF_00161 RuleBase RU004181

Ontologies

Keywords
Cellular component	Cell membrane HAMAP MF_00161 SAAS SAAS001872 Membrane
Domain	Transmembrane Transmembrane helix HAMAP MF_00161 SAAS SAAS001872
Molecular function	Aspartyl protease HAMAP MF_00161 RuleBase RU000594 SAAS SAAS001872 Hydrolase Protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	9 – 29	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	72 – 92	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	94 – 114	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	143 – 163	21	Helical; By similarity HAMAP MF_00161
Sites
	Active site	114	1	By similarity HAMAP MF_00161
	Active site	146	1	By similarity HAMAP MF_00161

Sequences

	Sequence		Length	Mass (Da)
	C0SX92 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 2F831E1D5416C3B5	FASTA	170	19,976
	10 20 30 40 50 60 MSAKSKQYFN IFVFIISLIF FDQLSKYLVA KYVKLGSIYF SFFDDFFRII HVRNTGILFS 70 80 90 100 110 120 MGSNIHYSLK KIFFLAMPIF ILIFVFYLSL KERNCIARIS LLLIFSGGVG NVIDRLFRPS 130 140 150 160 170 GVVDFLDLKF YGIFGLDRWP TFNFADSYVV IGMILFLVYD FFIKRKVLNK

References

[1]	Fraser-Liggett C.M., Mongodin E.F., Casjens B., Dunn J., Luft B., Qiu W., Schutzer S., Sebastian Y. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Bol26 EMBL EEH31722.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABCW02000003 Genomic DNA. Translation: EEH31722.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	29198946. VBIBorBur16602_0902.
Phylogenomic databases
OMA	LVEVWNS.
Family and domain databases
HAMAP	MF_00161. LspA. [Tree]
InterPro	IPR001872. Peptidase_A8. [Graphical view]
Pfam	PF01252. Peptidase_A8. 1 hit. [Graphical view]
PRINTS	PR00781. LIPOSIGPTASE.
TIGRFAMs	TIGR00077. LspA. 1 hit.
PROSITE	PS00855. SPASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C0SX92_BORBU

Accession

Primary (citable) accession number: C0SX92

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)