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C0SIM8

- MAP2_PARBP

UniProt

C0SIM8 - MAP2_PARBP

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Protein
Methionine aminopeptidase 2
Gene
PABG_07533
Organism
Paracoccidioides brasiliensis (strain Pb03)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei195 – 1951Substrate By similarity
Metal bindingi215 – 2151Divalent metal cation 1 By similarity
Metal bindingi226 – 2261Divalent metal cation 1 By similarity
Metal bindingi226 – 2261Divalent metal cation 2; catalytic By similarity
Metal bindingi295 – 2951Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei303 – 3031Substrate By similarity
Metal bindingi331 – 3311Divalent metal cation 2; catalytic By similarity
Metal bindingi426 – 4261Divalent metal cation 1 By similarity
Metal bindingi426 – 4261Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2 (EC:3.4.11.18)
Short name:
MAP 2
Short name:
MetAP 2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:PABG_07533
OrganismiParacoccidioides brasiliensis (strain Pb03)
Taxonomic identifieri482561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000002740: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Methionine aminopeptidase 2UniRule annotation
PRO_0000407660Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC0SIM8.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 7316Lys-richUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C0SIM8-1 [UniParc]FASTAAdd to Basket

« Hide

MAAQVASGVG NLNLNSEGGA AAKNISAQGS PENEARESDG EYDDDQGAPE    50
LGNTTAAKKK KKKTKKKKKG TSKVQTEPPR VILSSLFPNN QYPEGEIIEY 100
QNENAYRTTN EEKRHLDRMN NDFLAEYRYA AEVHRQVRQY SQKAIKPGQT 150
LTEIAEGIEE SVRALTGHPG LEEGDNLRGG IAFPTGVNLN HCAAHYTPNA 200
GNKMVLQYED VMKVDFGVHI NGRIVDSAFT IAFDPVYDNL LAAVKDATNT 250
GIKQAGIDVR MSDIGAAIQE AMESYEVEIK GTSYPVKAIR NLNGHTIGRY 300
EIHGGKNGKS VPIVKGGDQT KMEEGEVYAI ETFGSTGRGY VRDDMETSHY 350
AKIPDAPNVP LRLSSAKNLL NVITKNFGTL PFCRRYLDRL GQDKYLLGLN 400
NLVANGIVDA YPPLCDVKGS YTAQFEHTIL LRPNVKEVIS RGDDY 445
Length:445
Mass (Da):48,832
Last modified:May 5, 2009 - v1
Checksum:iE07BD9431161F9C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS544822 Genomic DNA. Translation: EEH18472.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS544822 Genomic DNA. Translation: EEH18472.1 .

3D structure databases

ProteinModelPortali C0SIM8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pb03.

Entry informationi

Entry nameiMAP2_PARBP
AccessioniPrimary (citable) accession number: C0SIM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi