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C0SGX7 (CBPYA_PARBP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:CPYA
ORF Names:PABG_06849
OrganismParacoccidioides brasiliensis (strain Pb03) [Complete proteome]
Taxonomic identifier482561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 131113 By similarity
PRO_0000407465
Chain132 – 550419Carboxypeptidase Y homolog A
PRO_0000407466

Sites

Active site2721 By similarity
Active site4631 By similarity
Active site5251 By similarity

Amino acid modifications

Glycosylation2031N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential
Glycosylation2891N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Disulfide bond185 ↔ 424 By similarity
Disulfide bond319 ↔ 333 By similarity
Disulfide bond343 ↔ 366 By similarity
Disulfide bond350 ↔ 359 By similarity
Disulfide bond388 ↔ 394 By similarity

Sequences

Sequence LengthMass (Da)Tools
C0SGX7 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: E186344B3C6D2D0E

FASTA55061,894
        10         20         30         40         50         60 
MKSLVLGLLV GSAIASGPLQ HVLHAPPDPE PKPEPEPQVV KDPFEELRDT FDRLRNKAGD 

        70         80         90        100        110        120 
IWDDVMDNIP NIMSNMRPLT IPAKKFTRRP DSEWTHIVRG ADLEALWVDD ESGYKHRKID 

       130        140        150        160        170        180 
GKLAQYDLRI KAVDPSDLGI DKVKQYSGYL DDNANDKHLF FWFFESRNDP FGDPVVLWLN 

       190        200        210        220        230        240 
GGPGCSSLTG MFFELGPASI DENITANYNP YSWNSNSSII FLDQPVNVGY SYSSQAVSDT 

       250        260        270        280        290        300 
VTAAKDVYAL LTLFFTQFRQ YSAQDFHIAG ESYAGHYIPV FASEILHHNN TNINLQSVLI 

       310        320        330        340        350        360 
GNGLTDPLSQ YPFYRPMACG DGGYPSVLDS QSCQSMDNAL PRCLSMIKSC YDIESTFTCL 

       370        380        390        400        410        420 
PASIYCNNAL IGPYQKTGRN PYDVRTNCTG NDLCYPQLNY ITEYLNKPHV MRSLGVEVDS 

       430        440        450        460        470        480 
YESCNMDINR NFLFHGDWMK PYHRLVPSLL ARIPVLIYAG DADFICNWLG NKAWTEALEY 

       490        500        510        520        530        540 
PGHAKFAEAP MENLTMINSQ GKNEVFGEVK SHSNLTFMRI FKAGHMTPFD SPQASLEFAN 

       550 
SWLSGEWSEV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS544816 Genomic DNA. Translation: EEH16762.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7XDBR1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_PARBP
AccessionPrimary (citable) accession number: C0SGX7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries