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C0SGJ2

- KEX1_PARBP

UniProt

C0SGJ2 - KEX1_PARBP

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Paracoccidioides brasiliensis (strain Pb03)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791By similarity
Active sitei381 – 3811By similarity
Active sitei443 – 4431By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PABG_06619
OrganismiParacoccidioides brasiliensis (strain Pb03)
Taxonomic identifieri482561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000002740: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 514487LumenalSequence AnalysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence AnalysisAdd
BLAST
Topological domaini536 – 635100CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 635608Pheromone-processing carboxypeptidase KEX1PRO_0000411933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiC0SGJ2.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0SGJ2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGFSGSRAWS KWLTICLAIT HPFSVTAKSA ADYYVHSLPG QPEGPLLKMH
60 70 80 90 100
AGHIEISPET SGNLFFWHFE NRHIADKPRT VVWLNGGPGC SSEDGALMEI
110 120 130 140 150
GPYRLIDKET LNYTEGSWDE FANLLFVDQP VGTGFSYGST EHYVHELDEM
160 170 180 190 200
ASQFVTFLEK WFEIFPHYEP DDLYFAGESY AGQYIPYIAR AVLDRNKKQD
210 220 230 240 250
VQANNRIWNL KGLLIGNGWI SPQHQYPAYL PYVYQEGVVQ AGTQEANLIE
260 270 280 290 300
AKAAKCMKEL NVEDTTGTVH IPDCEDILQA ILDYTHKGKR CINMYDIRLT
310 320 330 340 350
DDYSACGMNW PPDLRDIQPY LRRKDVVKAL HINEEKQTGW TECAGAVGSS
360 370 380 390 400
LKARNSKPAV ELLPGLLEEG LPILLFSGQK DLICNHVGTE DMIKNMKWSG
410 420 430 440 450
GTGFELSPGV WAPRQDWTFE GEPAGIYQQA RNLTYVLFYN ASHMVPFDYP
460 470 480 490 500
RRSRDMLDKF LGVDITHIGG DPADSRIDGE KGPTTSVGAH PNSTAAAERE
510 520 530 540 550
KEKLNTAAWK AYYKSGEVAL VIVAIAAFAW GIFIWRSRRK HQSSGYRSIY
560 570 580 590 600
PMLGLNSTGS LGQISHKHSR RNGDIEAADF DETELDDQPS QAFLSRSSRD
610 620 630
GDAYAVGEES SDEEDGASDG QQPMFDQSRG EEGRS
Length:635
Mass (Da):71,017
Last modified:May 5, 2009 - v1
Checksum:iBFDDCC0A0233F0A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS544815 Genomic DNA. Translation: EEH16532.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS544815 Genomic DNA. Translation: EEH16532.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi C0SGJ2.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pb03.

Entry informationi

Entry nameiKEX1_PARBP
AccessioniPrimary (citable) accession number: C0SGJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3