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C0S7H1 (DAPB_PARBP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:PABG_03771
OrganismParacoccidioides brasiliensis (strain Pb03) [Complete proteome]
Taxonomic identifier482561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Protein attributes

Sequence length911 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 911911Probable dipeptidyl-aminopeptidase B
PRO_0000412155

Regions

Topological domain1 – 9292Cytoplasmic Potential
Transmembrane93 – 11321Helical; Signal-anchor for type II membrane protein; Potential
Topological domain114 – 911798Vacuolar Potential

Sites

Active site7511Charge relay system By similarity
Active site8281Charge relay system By similarity
Active site8611Charge relay system By similarity

Amino acid modifications

Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation3461N-linked (GlcNAc...) Potential
Glycosylation5691N-linked (GlcNAc...) Potential
Glycosylation6561N-linked (GlcNAc...) Potential
Glycosylation8101N-linked (GlcNAc...) Potential
Glycosylation8971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C0S7H1 [UniParc].

Last modified May 5, 2009. Version 1.
Checksum: DEA2702BB20BBDAB

FASTA911102,212
        10         20         30         40         50         60 
MAAEKGGSSD EERKPLTRGG MEYRDSSNSL HYSSSAASLS LAVIDRINGS THDTGPDEIG 

        70         80         90        100        110        120 
RGDRDYSDDG EYDIEEADYI PSGGKPVQKK VKIVLGFLLF LCLSGWSLAF VLFLFGGHES 

       130        140        150        160        170        180 
SKTSIVYEDN ISDTGSQGIK ITLDEVFDGT WSPNSRDISW IPGPNGEDGL LLEKGASISN 

       190        200        210        220        230        240 
GYLRVEDIVS RKDPKSSKKP IVLMQKAYFN VSGEAVFPSR VWPSPDLKTV LVLSNEEKNW 

       250        260        270        280        290        300 
RHSFTGKYWL FDVESQTGQP LDPAAKDQRV QLASWSPRSD AVVFTRDNNM FLRKLSSNEV 

       310        320        330        340        350        360 
IKITTNGGVN LFYGVPDWVY EEEVFSGNSV TWWADDGEYI AFLRTNESSV PEYPVQYFVS 

       370        380        390        400        410        420 
RPNGEIPKPG GESYPETRKI KYPKAGAPNP IVDLQFFDVG KDEVFSVDIK GDFADSNRLI 

       430        440        450        460        470        480 
IEVVWASNGK VIVRSTNRES DVLHVAVIDV FSRTGKIVRK EDINALDGGW VEPSQTTRFI 

       490        500        510        520        530        540 
PADPDNGRLN DGYIDTVIYE GRDQLAYYTP IDNPKPIVLT NGHSEVVQAP SGVDLKRGLV 

       550        560        570        580        590        600 
YFVVAGNEPW ERHIYSVNFD GTSLQPVTNV SESSYYDVSF SNGAGYAFLK YAGPQVPWQK 

       610        620        630        640        650        660 
VISTPANEVT FEETIEENNH LSERLRQYTL ESKIYQYIDI DGFSLPVLER RPPNFNQTKK 

       670        680        690        700        710        720 
YPVLFYLYGG PGSQTVKKKF NVDFQSYVAA NLGYIVVTVD GRGTGFIGRK ARCIIRGNLG 

       730        740        750        760        770        780 
HFESRDQIQA AKIWAAKPYV DESRISIWGW SYGGFMALKT IEQDGGRTFK YGIAVAPVTD 

       790        800        810        820        830        840 
WRYYDSIYTE RYMHTPQRNP GGYDNAAISN TTALANNIRF LVMHGTADDN VHIQNSLTFI 

       850        860        870        880        890        900 
DKLDVNNVHN YDVHFFPDSD HSIYFHNAHK IVYSRLADWL VNAFNGEWLK TYDPTPNDSI 

       910 
LRRAATWVAS S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS544807 Genomic DNA. Translation: EEH21555.1.

3D structure databases

ProteinModelPortalC0S7H1.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_PARBP
AccessionPrimary (citable) accession number: C0S7H1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries